摘要
微粒(MP)是各种细胞激活和凋亡时产生的微小囊泡,具有促凝促栓的作用。溶血性贫血(HA)是指红细胞遭到破坏而寿命缩短,超过骨髓造血代偿时发生的一类贫血,其中镰状细胞贫血(SCD)、地中海贫血和阵发性睡眠性血红蛋白尿(PNH)皆存在高凝状态甚至血栓高发的特点。研究表明,HA中数量及功能异常的MP能促使HA高凝状态的形成并增加血栓栓塞(TE)风险。本文主要综述近年来细胞MP在HA高凝状态中的研究进展,详述了异常MP与HA高凝状态及临床相关血栓栓塞事件(TEE)的关系,以及HA相关治疗对MP的影响、MP在部分HA动物模型中的研究及近年来热点研究的MP蛋白组学在HA中的应用。
Microparticles (MP) are small membrane vesicles released from many different cell types in response to cellular activation or apoptosis, which have the procoagulant effect. Hemolytic anemia (HA) is a type of anemia that have a short life expectancy of red blood cells due to the destruction which exceed the hematopoietic compensatory capacity of bone marrow. Sickle cell anemia( SCD), thalassemia and paroxysmal nocturnal hemoglobinuria(PNH) are all characterized by hypercoagulation and thromboembolism (TE). Research shows that MP can promote the formation of hypercoagulative state which in turn increases the risk of the advance research of MP in HA in the past 5 years thromboembolism in HA. Moreover the relationship This review mainly summarized between the abnormal MP and hypercoagulation in HA, the impact of the related treatment to the MP, the research of MP in animal model of HA and the application of the MP-proteomics in HA are also disscussed.
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2017年第2期622-626,共5页
Journal of Experimental Hematology
关键词
微粒
溶血性贫血
高凝状态
血栓栓塞
microparticle
hemolytic anemia
hypercoagulation
thromboembolism