摘要
目的探明心肺复苏后亚低温治疗最佳的目标温度设置,从而改善CA患者的生存率及神经功能。方法本研究为观察性研究,纳入2014年10月至2016年10月的心脏骤停后自主循环恢复的病例165例,依据入院时目标温度设置分为34~36℃组(实验组)与32~34℃组(对照组),比较两组间不良事件发生率、出院时存活率、良好神经功能预后率之间的差异。结果两组相比出院时存活率差异无统计学差异(χ~2=0.29 df=1 P=0.35);出院时神经功能预后良好率之间差异无统计学意义(χ~2=0.67 df=1 P=0.25);34~36℃组有更低的低钾血症发生率(χ~2=2.38 df=1 P=0.09);而在心律失常及肺炎的发生率方面的差异无统计学意义。结论心脏骤停患者自主循环恢复后的亚低温治疗中,目标温度设置为34~36℃与32~34℃相比对预后的影响没有差异但有更低的低钾血症发生率。
Objective To determine the optimal targeted temperature that could improve the survival and neurological outcome after cardiac arrest. Methods We conducted a retrospective observational study from a signal center. We included 165 comatose adult patients with ROSC after cardiac arrest from 1 st, October 2014 to 31 st, October 2016, which were divided into two groups according to the different targeted temperature after ROSC（34 - 36℃ vs 34 - 36℃ ）. The primary outcomes were survival at discharge and good neurological outcome. The secondary outcomes included serious adverse events. Results The groups did not differ significantly with respect to the survival at discharge （x^2 = 0. 29 df = 1 ,P =0. 35） and good neurological outcome （x^2 =0. 67 df= 1 P =0. 25）. The 34 -36℃ group has a lower occurrence rate of Hypokalemia while the rates of arrhythmia and pneumonia have no significantly difference between the two groups. Conclusion There are no significantly difference in comatose adult patients with ROSC after cardiac arrest treated with TTM at 34℃- 36℃ compared to 32℃ - 34℃ in survival at discharge and good neurological outcome respectively. The 34 - 36℃ group has a lower occurrence rate of Hypokalemia.
出处
《医药论坛杂志》
2017年第2期1-3,7,共4页
Journal of Medical Forum
基金
河南基础研究计划项目(132300410046)
关键词
心脏骤停
目标温度
预后
Cardiac arrest
Targeted Temperature
Prognosis
