摘要
目的制备甘草次酸修饰的黄芩苷脂质体。方法采用化学合成甘珀酸十八醇酯(18-GA-Suc)作为两亲性导向分子,从稳定性、包封率等方面考察制备甘草次酸修饰的黄芩苷脂质体的最佳方法,单因素和正交试验优选甘草次酸修饰的黄芩苷脂质体的处方和工艺。结果根据优化工艺制备的甘草次酸修饰的黄芩苷脂质体外观为乳白色,带有淡蓝色乳光,无絮凝现象,包封率为41.75%。结论甘草次酸修饰的黄芩苷脂质体制备成功,并以包封率为指标对其制备工艺进行优化,可为其肝靶向研究奠定基础,有望成为肝肿瘤靶向的新型载体。
Objective To prepare baicalin liposomes modified with glycyrrhetinic acid. Methods The carbenoxolone eighteen alcohol ester （18-GA-Suc）by chemical synthesis method was as amphiphilic guidance molecule. The optimal method was investigated from its stability, encapsulation efficiency. The single factor and orthogonal test was used to optimize the pre-scription and process. Results According to the optimized process, the appearance of the baicalin liposomes modified by the glycyrrhetinic acid was milky white, with pale blue light and no flocculation, and the encapsulation efficiency was for 41.75%. Conclusion The preparation technology of baicalin was successfully prepared, and the process was optimized by the index of encapsulation efficiency, which could provide the basis for liver targeted research.
出处
《湖南中医药大学学报》
CAS
2017年第4期373-377,共5页
Journal of Hunan University of Chinese Medicine
基金
湖南省"十二五"中药学重点学科建设项目(湘教通[2011]76号)
2016年湖南省创新课题(CX2016B346)
关键词
甘草次酸
黄芩苷
脂质体
glycyrrhetinic acid
baicalin
liposomes
