摘要
目的:探讨产前孕妇凝血酶原时间(PT)、活化部分凝血活酶时间(a PTT)、凝血酶时间(TT)、纤维蛋白原(Fbg)及联合抗凝血酶(AT)、D-二聚体(D-D)检测的临床意义。方法:以2014年8月至2015年10月接受产前检查的180例孕妇为观察对象,同时选取180例未妊娠健康女性作为对照组。观察两组PT、a PTT、TT、Fbg水平和AT、D-D水平的差异。分析PT、a PTT、TT、Fbg水平与AT、D-D水平的相关性。结果:观察组孕妇的PT、a PTT、TT水平分别为(10.02±1.03)、(26.12±3.68)、(10.13±2.36)s,明显低于对照组,而Fbg水平为(4.89±0.35)g·L-1,明显高于对照组,差异均具有统计学意义(P<0.001);观察组孕妇的AT水平[(64.68±9.35)%]明显低于对照组(t=20.832,P<0.001),而D-D水平为(759.56±26.82)ng·ml-1,明显高于对照组,差异具有统计学意义(t=-23.286,P<0.001);AT与PT、a PTT和TT呈正相关,与Fbg水平呈负相关,D-D水平与PT、a PTT和TT呈负相关,与Fbg水平呈正相关,均P<0.05。结论:产前孕妇的PT、a PTT、TT和AT水平较低,Fbg和D-D水平较高,可作为临床监测的重要指标。
Objective： To detect the clinical significance of prenatal prothrombin time （PT）, activated partial thromboplastin time （aPTT）, thrombin time （TT）, fibrin original （Fbg） and antithrombin （AT）, D-Dimer （D- D）. Methods： One hundred and eighty pregnant women who received prenatal examination in our hospital from October to August 2014 were selected as the observation objects, and 180 cases of non pregnant women were selected as control group. The levels of PT, aPTT, TT, Fbg and AT, D-D were observed. The correlation of TT, aPTT, TTT, Fbg and AT, D-D was analyzed. Results： The level of Pt, APTT, TT in the observation group was （ 10.02 ＋ 1.03 ）, （26. 12 ＋ 3.68 ）, （ 10. 13 ＋ 2.36 ） s, which were significantly lower than that of the control group, respectively ; and the level of FBG was （4.89 ＋ 0.35 ） g · L^-1, significantly higher than that of the control group with a statistieal significance （P 〈 0. 001 ）. The level of AT in observation group was （64.68 ＋ 9.35 ）%, significantly lower than that in the control group （ t = 20.832,P 〈 0.001 ）, and the level of D- dimer was （759.56 ＋ 26.82）ng· ml^-1, significantly higher than that of the control group with a statistical difference （t =-23. 286, P 〈 0. 001 ）. AT was positively correlated with PT, aPTT and TT, and negatively correlated with Fbg level; the level of D-D; were negatively correlated with PT, aPTT and TT, and positively correlated with Fhg level with statistical significances （P 〈 0.05 ）. Conclusion： The levels of PT, aPTT, TT and AT in prenatal pregnant women are low, and the levels of Fbg and D-D are high, which can be used as an important index for clinical monitoring.
出处
《现代医学》
2017年第1期109-113,共5页
Modern Medical Journal
关键词
孕妇
D-二聚体
凝血酶原
相关分析
纤维蛋白原
pregnant women
D-two polymer
prothrombin
correlation analysis
fibrous protein
