摘要
目的比较两种初始经验治疗方案治疗腹膜透析相关性腹膜炎的疗效和安全性。方法回顾性分析2011年1月至2016年10月在沈阳军区总医院行腹膜透析且发生腹膜炎的362例患者的临床资料,根据初始抗菌治疗方案分为A方案组(万古霉素联合1种覆盖G-菌药物)和B方案组(头孢唑林联合1种覆盖G-菌药物),初始治疗采用A方案198例,B方案105例,其他方案59例。比较两组方案的疗效和安全性。结果本研究中,G+菌为主要病原菌(66.11%)。两组患者的初始治疗有效率、3周后治疗有效率、总住院天数、抗菌药使用天数和转归比较,差异均无统计学意义(P>0.05);两组肾功指标除治疗后血尿素水平均较治疗前有所降低外(P<0.05),其余差异无统计学意义(P>0.05)。结论两种初始经验治疗方案治疗腹膜透析相关性腹膜炎的疗效相当,且安全性均较好。
Objective To compare the efficacy and safety of two initial treatments on peritoneal dialysis-related peritonitis.Methods A retrospective study was performed on 362 patients with peritoneal dialysis-related peritonitis who were admitted from January 2011 to October 2016. According to their initial therapy,patients were divided into Group A（ vancomycin plus a kind of antibiotics of Gram-negative bacteria） and Group B（ cefazolin plus a kind of antibiotics of Gram-negative bacteria）. There are 198 cases in Group A,105 cases in Group B and the remaining,other 59 cases in other method. The efficacy and safety were compared between the two groups. Results G＋bacteria（66. 11%） was the main pathogenic bacteria. There were no significant difference in primary efficiency,3 weeks treatment efficiency,total hospital days,use of antimicrobial agents days or the regression between the two groups（ P〈0. 05）.Except the blood urea after the treatment was lower than that before,the renal function indices had no statistically significant difference in Group A and Group B during the therapy（ P〈0. 05）. Conclusion The two initial treatments have similar efficacy and safety for peritoneal dialysis related peritonitis.
出处
《临床军医杂志》
CAS
2017年第3期300-303,共4页
Clinical Journal of Medical Officers
关键词
腹膜透析
腹膜炎
头孢唑林
万古霉素
Peritoneal dialysis
Peritonitis
Cefazolin
Vancomycin
