摘要
目的分析干燥综合征(SS)合并中轴型脊柱关节炎(axSpA)的临床相关因素,从而提高对此类疾病的认识。方法收集SS合并axSpA的31例患者临床资料,并选择113例同期收治的性别、年龄相匹配的原发性干燥综合征(pSS)患者为对照,从一般资料、临床表现、实验室检查和多系统损伤等方面进行分析。结果SS合并axSpA患者组关节表现和内脏损害多,该组关节痛、红细胞沉降率升高、C反应蛋白增高、抗Ro-52抗体阳性、肺部损害、肾损害和血液系统受累的比例均高于pSS组,差异有统计学意义(P<0.05);但两组间口眼干、抗核抗体(ANA)、抗SSA抗体、抗SSB抗体、腮腺造影、Schirmer试验、角膜染色、心脏损害、肝损害和神经损害,均差异无统计学意义(P>0.05)。结论 SS合并axSpA患者关节表现和内脏损害多且严重,尤以肺部、肾脏和血液系统明显;同时病情活动度高、进展快。
Objective Objective Analyze clinical relative factors of Sjogren^ syndrome （SS） combined axis Spondyloarthritis （ SpA） ,so as to improve the understanding of this disease. Methods Thirty-one cases of SS combined axSpA were investigated, and 113 cases of primary Sjogren^ syndrome patients with matched sex and age during the same period were chosen as the control group. The general information, clinical characteristics, laboratory examinations and organ or system damages of two groups were analyzed. Results Articular symptom and internal organ damages of SS combined axSpA group are more serious than the control group. Some aspects including arthralgia, erythrocyte sedimenta-tion rate,C-reactive protein, anti Ro-52 antibody, lung damage, renal injury and hematologic system damage of the SS combined axSpA group have significantly higher rate than the control group （P 〈0. 05） . There are no statistic differences in other features between two groups （P 〉 0. 05 ） . Conclusion Articular symptom and internal organ damages of SS combined axSpA group are very serious,especially in lung,kidney and hematologic system. In addition,its disease activi-ty is high ; progress is fast. So it is important to diagnose timely and give active treatment as soon as possible.
出处
《中国临床保健杂志》
CAS
2017年第2期122-124,共3页
Chinese Journal of Clinical Healthcare
基金
首都医学发展基金(首发-1-4051)
关键词
干燥综合征
椎关节炎
危及器官
Sjogren＇s syndrome
Spondylarthritis
Organs at risk
