摘要
目的探讨内镜黏膜下剥离术(ESD)治疗直肠神经内分泌肿瘤(NENs)的安全性及临床疗效评价。方法对2010年5月至2016年10月经南京中医药大学附属江苏省中医院消化内镜中心行内镜下治疗的38例直肠NENs患者的临床资料进行回顾性分析,所有患者均接受ESD治疗,本文对其内镜下表现特点、并发症及疗效等数据进行总结。结果 38例直肠NENs患者均成功地接受ESD治疗,平均手术时间(26.5±7.2)min,所有标本全部经病理确诊,基底切缘和侧切缘均未见病变累及,整块切除率为97.4%。共有2例出现术后迟发性大出血,无穿孔、感染等并发症发生。术后病理分级:G1、G2和G3期分别为36例、2例和0例。术后随访1~74个月,仅1例患者出现复发。结论 ESD治疗不超过15 mm的且未侵犯固有肌层的直肠NENs安全、有效。
Objective To explore the safety and clinical effects of endoscopic submucosal dissection （ESD） for rectal neuroendocrine neoplasms （ NENs） . Methods Retrospective analysis was made for 38 cases of rectal NENs with endoscopic therapy between May 2010 and October 2016. All patients underwent ESD. Endoscopic manifestations were summarized and the related data such as therapeutic effects and complications were reviewed. Results Thirty-eight cases were all successfully treated with ESD. Mean operative time was （26.5 ±7. 2） min. All lesions were resected with lateral and basal resection margins free of tumor and the en bloc resection rate was 97. 4%. Among all the cases, delayed massive bleeding occurred in 2 patients. The bleeding rate was 5. 3% （2/38）. No complications such as perforation and infection occurred. Postoperative pathological results revealed that 36 cases were of G1 stage and 2 of G2 stage. No residual lesion occurred and only 1 case recurred during the follow-up period of 1-74 months. Conclusions ESD is safe and effective in treatment of patients with rectal NENs without muscularis propria invasion,which are not bigger than 15 mm.
出处
《中华胃肠内镜电子杂志》
2017年第1期6-9,共4页
Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition)
关键词
直肠神经内分泌肿瘤
类癌
内镜黏膜下剥离术
Rectal neuroendocrine neoplasms （ r-NENs ）
Carcinoid tumors
Endoscopicsubmucosal dissection
