摘要
目的:观察手足浸泡方治疗化疗后手足综合征(hand-foot syndrome,HFS)的临床疗效。方法:将79例HFS患者随机分为对照组A 30例、对照组B 19例和治疗组30例。各组均给予化疗,化疗开始时即予下述治疗:治疗组予手足浸泡方,对照组A给予质量分数0.3%聚维酮碘,对照组B口服维生素B6。观察各组患者的临床疗效、总化疗时间及治疗前后神经电生理变化情况。结果:对照组A有效率为70.0%,对照组B有效率为63.2%,治疗组有效率为86.7%,三组比较,差异具有统计学意义(P<0.05)。治疗组、对照组A、对照组B总化疗时间分别为(4.24±1.02)个月、(6.20±1.35)个月、(6.51±1.41)个月,治疗组与其他两组比较,差异均有统计学意义(P<0.05)。各组患者治疗前后神经生理变化比较,差异均无统计学意义(P>0.05)。结论:手足浸泡方能显著减轻化疗后手足综合征的症状,提高患者对化疗的耐受性,改善患者的生活质量。
Objective： To observe the clinical curative effect of Hand-Foot Soaking Decoction on hand-foot syndrome（ HFS）.Methods： Seventy-nine patients were randomly divided into the control group A with 30 cases,the control group B with 19 cases and the treatment group with 30 cases. Each group was given chemotherapy. Since the beginning of chemotherapy,the ones in the treatment group were treated with Hand-Foot Soaking Decoction; The ones in the control group A were treated with povidone iodine with 0. 3% of mass fraction; The ones in the control group B were treated with vitamin B6 for oral administration. Then the three groups＇ clinical curative effects,total chemotherapy time,and the changes of electrophysiology before and after treatment were observed. Results： The effective rate of the control group A was 70%,while that of the control group B 63. 2%,and that of the treatment group was 86. 7%; The differences between the three groups were statistically significant（ P〈0. 05）. The total chemotherapy time of the treatment group,the control group A and the control group B was（ 4. 24 ± 1. 02） months,（ 6. 20 ± 1. 35） months and（ 6. 51 ± 1. 41） months respectively. The differences between the treatment group and the other two groups were statistically significant（ P〈0. 05）. There was no significant difference in neurophysiological changes before and after the treatment in each group（ P〉0. 05）. Conclusion： Hand-Foot Soaking Decoction can significantly reduce the symptoms of hand foot syndrome after chemotherapy,improve the patient＇s tolerance to chemotherapy and improve their quality of life.
出处
《河南中医》
2017年第4期703-705,共3页
Henan Traditional Chinese Medicine
基金
湖南省教育厅科研课题(编号:12C0529)
关键词
手足综合征
手足浸泡方
中药浸泡
化疗
hand-foot syndrome（HFS）
Hand-Foot Soaking Decoction
Chinese medicine soaking
chemotherapy
