摘要
目的评价集束化方案治疗急性脑损伤(ABI)合并急性肺损伤(ALI)/急性呼吸窘迫综合征(ARDS)的有效性及安全性。方法将83例ABI合并ALI/ARDS患者随机分为实验组(n=41)和对照组(n=42),对照组采用常规集束化方案,实验组采用强化集束化方案。检测2组患者治疗前后的各项指标,评价2种方案治疗ABI合并ALI/ARDS的有效性及安全性。结果 2组患者治疗前后心率、Sp O2、PO2/Fi O2比较均有统计学差异(P<0.05);与对照组比较,实验组PO2/Fi O2改善更早、更明显,机械通气时间、入住ICU时间、总住院时间均有统计学差异(P<0.05),而28 d病死率及呼吸机相关性肺炎发病率无统计学差异(P>0.05)。结论集束化方案治疗ABI合并ALI/ARDS有效;与常规方案相比,强化方案能显著改善氧合,缩短机械通气、入住ICU及总住院时间。
Objective To evaluate the efficacy and safety of the bundles of treatment protocol for patients with acute brain injury（ABI）complicated by acute lung injury（ALI）/acute respiratory distress syndrome（ARDS）. Methods A total of 83 patients with acute brain injury complicated by ALI/ARDS were randomly divided into experimental group（n = 41）and control group（n = 42）.The control group was treated with the routine bundle protocol while the experimental group was treated with an intensive bundle protocolin addition to the routine bundle protocol. The data was collected,and the effectiveness and safety of the two bundles of treatment protocol were evaluated. Results The results of heart rate（HR）,Sp O2,and PO2/Fi O2 in the two groups showed significant differences before and after treatment.The improvement of PO2/Fi O2 in the experimental group occurred earlier and was more significant compared tothe control group,24 hours after treatment.The mechanical ventilation time,ICU stay time,and total hospitalization time for the experimental group were significantly different（P 〈 0.05）from the control group.The 28-day mortality and morbidity of ventilator-associated pneumonia showed no significant difference（P 〉 0.05） between the two groups. Conclusion The treatment of acute brain injury complicated by ALI/ARDS by the two bundles of treatment protocol is effective. Compared to the conventional treatment bundles,the intensive treatment bundles can significantly improve oxygenation,and shorten the mechanical ventilation time required,as well as ICU and total hospital stay.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2017年第4期317-320,共4页
Journal of China Medical University
基金
辽宁省自然科学基金(2014021097)
关键词
急性脑损伤
急性肺损伤
急性呼吸窘迫综合征
集束化方案
acute brain injury
acute lung injury
acute respiratory distress syndrome
bundles of treatment protocol
