摘要
目的:比较艾灸肾俞穴与天然维生素E对绝经前后亚健康状态女性生存质量影响,并探讨部分作用机制,为艾灸应用亚健康女性保健提供参考。方法:将60例受试者随机分为艾灸组和药物组,每组30例。艾灸组选取肾俞穴,温和灸15min,每日1次,连续5d为一疗程,间隔2d,持续干预4个疗程。药物组每日口服一粒天然维生素E软胶囊,连服28d。检测受试者干预前后生存质量简表评分,血清性激素以及抗苗勒管激素(AMH)、抑制素B(INHB)水平。结果:1干预后两组生存质量简表评分与干预前比较均显著提高(均P<0.01),且艾灸组优于药物组(P<0.05)。2艾灸组干预后血清雌二醇(E2)、孕酮(P)水平与干预前比较明显提高(均P<0.01),尤其对未绝经受试者效果显著(均P<0.01)。3艾灸干预后血清AMH水平较干预前显著提高(P<0.01),对INHB影响差异不具有统计学意义(P>0.05)。结论:艾灸可以有效提高绝经前后亚健康状态女性的生存质量,调节其性激素及血清AMH水平,提高卵巢储备功能,延缓卵巢衰老。
Objective To compare the effects between moxibustion at Shenshu（BL 23）and oral administration of Vitamin E on quality of life and mechanism in sub-health perimenopausal women,aiming to provide clinical evidence of moxibustion for health care of sub-health female.Methods Sixty participants were randomly divided into a moxibustion group and a medication group,30 cases in each one.The volunteers in the moxibustion group were treated with mild moxibustion at bilateral Shenshu（BL 23）for 15 min,once a day;five treatments were considered as a course of treatment,and totally 4courses were given with an interval of 2days between courses.The volunteers in the medication group were treated with oral administration of soft capsule of Vitamin E,once a day,continuously for 28 days.The scores of quality of life and serum levels of sex hormones,anti-Mullerian hormone（AMH）and inhibin B（INHB）were measured before and after treatment in the two groups.Results 1 Compared before treatment,the scores of quality of life in the two groups were both significantly increased after treatment（both P〈0.01）,which was more superior in the moxibustion group（P〈0.05）.2 Compared before treatment,the serum levels of estradiol（E2）and progesterone in the moxibustion group were significantly increased after treatment,especially for premenopausal volunteers（both P〈0.01）.3 After moxibustion,the serum level of AMH was significantly improved（P〈0.01）,however,the effect on INHB had no statistical difference（P〉0.05）.Conclusion Moxibustion could effectively improve the quality of life in sub-health perimenopausal women,regulate the levels of sex hormones and AMH,improve ovarian reserve function,and delay ovarian aging.
出处
《中国针灸》
CAS
CSCD
北大核心
2017年第4期381-385,共5页
Chinese Acupuncture & Moxibustion
基金
江苏省中医药局科技项目:LZ13008
南京中医药大学青年自然科学基金项目:13XZR15
