摘要
目的了解食管癌患者血清维生素E水平,为食管癌的防治及病因探索提供参考依据。方法检索中国知网数据库、万方数据库、Pub Med数据库、Web of Science数据库,并辅以手工检索和文献追溯法收集1980年1月—2015年12月公开发表的关于食管癌患者血清维生素E水平的相关文献;采用Stata 12.0软件对纳入的文献进行meta分析。结果最终纳入9篇文献(中文文献7篇,英文文献2篇),累计病例组患者358例,对照组人群538例;meta分析结果显示,病例组食管癌患者血清维生素E水平较对照组人群低(SMD=-0.50,95%CI=-0.65^-0.36,P<0.001);亚组分析结果显示,国家为中国(SMD=-0.50,95%CI=-0.67^-0.33)和其他国家(SMD=-0.51,95%CI=-0.77^-0.25)、对照来源于社区(SMD=-0.54,95%CI=-0.69^-0.39)、样本量>50例(SMD=-0.56,95%CI=-0.71^-0.41)、年龄匹配(SMD=-0.57,95%CI=-0.72^-0.42)、测定方法为高效液相色谱法(SMD=-0.41,95%CI=-0.59^-0.24)和其他方法(SMD=-0.67,95%CI=-0.91^-0.43)的研究中病例组食管癌患者血清维生素E水平均低于对照组人群(均P<0.001);敏感性分析和发表偏倚检验结果显示,本研究meta分析结果稳定,且不存在发表偏倚。结论食管癌患者血清维生素E水平较低。
Objective To explore the association between esophageal cancer and serum vitamin E level and to pro- vide evidences for researches and prevention of esophageal cancer. Methods Case-control studies on esophageal cancer and serum vitamin E level published from January 1980 to December 2015 were searched through China National Knowl- edge Infrastructure, Wanfang Database, PubMed, and Web of Science. Meta-analysis was performed with Stata 12. 0. Results A total of 9 literatures （7 in Chinese and 2 in English） ,involving in 358 esophageal cancer cases and 538 controis ,were included in the meta-analysis. The meta-analysis showed that the serum vitamin E level of esophageal cancer cases was lower than that of the controls （ standardized mean difference [ SMD ] = - 0. 50,95 % confidence interval [ 95 % CI] = - 0. 65 - 0. 36, P 〈 0. 001 ）. Subgroup analysis found that the serum vitamin E levels of the esophageal cancer cases were lower than those of the controls for the studies conducted in China （ SMD = - 0. 50,95% CI = - 0. 67 - 0. 33 ） and in United States （ SMD = - 0. 51,95 % CI = - 0. 77 - 0. 25 ）, with the controls selected from communities （ SMD = - 0. 54,95 % CI = - 0. 69 - 0. 39 ）, with the sample size of larger than 50 （ SMD = - 0. 56,95 % CI = -0. 71 - 0. 41 ）, with age-matched controls （ SMD = - 0. 57,95 % CI = - 0. 72 - 0.42）, and with serum vitamin E level detection using high performance liquid chromatography （HPLC） （ SMD = - 0. 41,95% CI = - 0. 59 - 0. 24） and using method other than HPLC （ SMD = - 0. 67,95% CI = - 0. 91 - 0. 43 ） （ all P 〈 0. 001 ）. Sensitivity analysis and publication bias test showed that the results of the study were stable and there was no publication bias for the literatures included in the study. Conclusion Serum vitamin E level is low in esophageal cancer patients.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2017年第4期681-684,共4页
Chinese Journal of Public Health
基金
国家自然科学基金(81402670)
