摘要
^(18)F-氟化钠是一种正电子发射计算机断层显像(PET)药物,主要用于成骨性反应活跃的骨疾病、尤其是恶性肿瘤骨转移的诊断。^(18)F-氟化钠PET骨显像具有高灵敏度和高特异性的特点,能更早发现99 Tcm-亚甲基二膦酸盐(99 Tcm-MDP)单光子发射计算机断层显像(SPECT)不能探测到的病灶。这对肿瘤治疗方案的选择和预后判断具有重要的临床意义。另外,18 F-氟化钠也能够有效鉴别破裂高风险的冠状动脉粥样硬化斑块。本工作就PET显像剂^(18)F-氟化钠的制备、质量控制、药理作用、辐射安全和临床应用作出综述。
Sodium ^18F-fluoride is a radioactive diagnostic agent for positron emission tomography（PET）indicated for imaging of bone to define areas of altered osteogenic activity,especially used to diagnosis of tumor bone metastases.The characteristics of sodium ^18Ffluoride PET bone imaging are high sensitivity and high specific,and it can earlier find more lesions that 99 Tcm-methylene diphosphonate（99 Tcm-MDP）single-photon emission computed tomography（SPECT）imaging can not find.It is very important to the choice of tumor treatment plan and prognosis.Moreover,sodium^18F-fluoride can be used to effectively identify vulnerable coronary atherosclerotic plaque.This review provides a critical and thorough overview of the preparation,quality control,pharmacological effects,radiation safety and clinical application of PET imaging agent sodium ^18F-fluoride.
出处
《核化学与放射化学》
CAS
CSCD
北大核心
2017年第2期138-144,共7页
Journal of Nuclear and Radiochemistry
