摘要
目的探讨LDL-C与非瓣膜性心房颤动（房颤）患者缺血性卒中的相关性。方法非瓣膜性房颤患者2470例，记录患者临床资料及入院后实验室检查结果。按有元缺血性卒中病史分为无缺血性卒中史组（1910例）和有缺血性卒中史组（560例）；根据CHA2DS2-VASe评分分为低中危组（〈2分，566例）和高危组（〉t2分，1904例），分别比较两组各项临床指标的差别，并进一步探讨非瓣膜性房颤患者LDL-C与缺血性卒中的关系。结果无缺血性卒中史组与有缺血性卒中史组汉族比例、性别比、年龄、血红蛋白、红细胞压积、ALT、血尿酸、HDL-C、LDL-C差异均有统计学意义（P〈0．05）。低中危组和高危组汉族比例、性别比、年龄、白细胞计数、血红蛋白、红细胞压积、血小板计数、ALT、白蛋白、TG、LDL-C差异均有统计学意义（P〈0．05）。LDL．C为非瓣膜性房颤患者缺血性卒中史的独立危险因素（OR2．089，95％CI1．860～2．347，P〈0．05），LDL-C为非瓣膜性房颤患者缺血性卒中风险的独立危险因素（OR 1．270，95％CI1．079-1．494，P〈0．05）。结论LDL-C与非瓣膜性房颤患者缺血性卒中相关，且为非瓣膜性房颤患者缺血性卒中的独立危险因素。
Objective To evaluate the association between LDL-C and ischemic stroke in patients with nonvalvular atrial fibrillation （ AF）. Method A total of 2 470 patients with nonvalvular AF were included in the present study. The clinical data and laboratory examination results of the patients in the hospital were collected. The subjects were either divided into the ischemic stroke history （n = 560 ） , and non- ischemic stroke history groups （n = 1 910） , or divided into the low-middle risk （n = 566 ） and high risk groups （n = 1 904） based on CHA2 DS2- VASc score. Results There were significant differences in the proportion of Han, the ratio of gender, age, hemoglobin, hematocrit, ALT, serum uric acid, HDL-C and LDL-C between the patients with ischemic stroke history and without （ all P 〈 0. 05 ）. Similarly, there were significant differences in the proportion of Han, the ratio of gender, age, white blood cell count, hemoglobin, hematocrit, platelet count, ALT, albumin, TG and LDL-C between subjects in the low-middle risk group and those in the high risk group （ all P 〈 0.05 ）. A logistical regression analysis showed that LDL-C was an independent risk factor for both the ischemic stroke history （ OR 2.089, 95% CI 1. 860 - 2. 347, P 〈0. 05）, and future ischemic stroke risk （ OR 1. 270, 95% CI 1. 079 - 1. 494, P 〈 0. 05） in patients with nonvalvular AF. Conclusion LDL-C is associated with ischemic stroke in patients with nonvalvular AF, and it is also an independent risk factor for future ischemic stroke in these patients.
出处
《中华内科杂志》
CAS
CSCD
北大核心
2017年第4期258-262,共5页
Chinese Journal of Internal Medicine
基金
新疆维吾尔自治区科技支撑计划（201333117）
