摘要
Killer cell immtmoglobulin-like recep- tors （KIRs） are transmembraneglycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic, highly homolo- gous and found in a duster on chromo- some 19q13.4 within the 1 Mb leukocyte receptor complex. The gene content of the KIR gene cluster varies among haplotypes, although several frame- work genes are found in all haplotypes （including KIR3DL3, KIR3DP1, KIR2DL4 and KIR3DL2）. In spite of the extended diversity of the KIR genomic region, these four framework loci are nearly ubiquitous in the population, and the pseudogene （KIR3DPI） is not expressed.1
Killer cell immtmoglobulin-like recep- tors （KIRs） are transmembraneglycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic, highly homolo- gous and found in a duster on chromo- some 19q13.4 within the 1 Mb leukocyte receptor complex. The gene content of the KIR gene cluster varies among haplotypes, although several frame- work genes are found in all haplotypes （including KIR3DL3, KIR3DP1, KIR2DL4 and KIR3DL2）. In spite of the extended diversity of the KIR genomic region, these four framework loci are nearly ubiquitous in the population, and the pseudogene （KIR3DPI） is not expressed.1
