摘要
目的观察阿托伐他汀联合曲美他嗪在不稳定型心绞痛临床治疗中的效果。方法采用简单随机方法将60例不稳定型心绞痛患者随机分为对照组和观察组,每组30例。两组患者均给予常规对症支持治疗,对照组在常规治疗的基础上给予阿托伐他汀治疗,观察组在常规治疗的基础上给予阿托伐他汀联合曲美他嗪治疗,比较两组患者的治疗总有效率,治疗前、后血脂指标改善情况及不良反应发生情况。结果治疗8周后,观察组患者的总有效率达93.3%,高于对照组的73.3%(P<0.05);观察组患者TC、TG、LDL-C水平显著低于对照组,HDL-C含量显著高于对照组(P<0.05);观察组患者的LVESD、LVEDD水平与对照组相比显著降低,LVEF水平与对照组相比显著升高(P<0.05);两组患者的不良反应发生率差异不显著(P>0.05)。结论采用阿托伐他汀联合曲美他嗪治疗不稳定型心绞痛,临床效果显著,安全性好,值得推广应用。
Objective To observe the effect of atorvastatin combined with trimetazidine in the treatment of unstable angina. Methods Sixty cases of patients with unstable angina were randomly divided into control group and observation group, with 30 cases in each group. The two groups were given conventional support treatment, the control group was given atorvastatin on the basis of conventional treatment, while the observation group was given atorvastatin with trimetazidine on the basis of conventional treatment. The total effective rate, blood lipid indexes before and after treatment and adverse reactions occurrence rate were compared between the two groups. Results After 8 weeks treatment, the total effective rate of the observation group was 93.3%, which was significantly higher than 73.3% of the control group （P〈0.05）; the levels of TC, TG and LDL-C of the observation group were significantly lower than those of the control group, the level of HDL-C was significantly higher than that of the control group （P〈0.05）; the levels of LVESD and LVEDD in the observation group were significantly lower than those of the control group, the LVEF level were significantly higher than that of the control group （P〈0.05）; the difference of adverse reactions incidence rates had no statistical significance between the two groups （P 〉0.05）. Conclusion The clinical effect of atorvastatin combined with trimetazidine in the treatment of patients with unstable angina is remarkable, it was of high security, which is worthy of clinical popularization and application.
作者
马有利
MA You-li(Worker＇s Hospital of Xi＇an Coal Mine Machinery Factory, Xi＇an 710032, China)
出处
《临床医学研究与实践》
2017年第11期8-9,共2页
Clinical Research and Practice
