摘要
目的观察不同剂量阿司匹林联合氯吡格雷治疗老年不稳定型心绞痛的疗效。方法将不稳定型心绞痛患者150例随机分为A、B、C 3组,每组50例。分别给予阿司匹林50 mg/d、75 mg/d、100 mg/d,3组均与氯吡格雷75 mg/d双联抗血小板治疗1年,均给予标准的冠心病二级预防。比较治疗后1个月和1年内各组主要心血管事件和不良反应。结果治疗1个月时A组患者主要心血管事件发生率高于B组和C组(P<0.05),B组和C组比较差异无统计学意义(P>0.05);3组不良反应比较差异无统计学意义(P>0.05)。随访1年后发现,A、B、C3组之间主要心血管事件发生率无明显差异(P>0.05);C组轻微不良反应发生率高于A组与B组(P>0.05);但严重不良反应发生率3组之间无明显差异(P>0.05)。结论阿司匹林50 mg、75 mg联合氯吡格雷治疗老年不稳定型心绞痛安全、有效,相较100 mg的标准剂量不良反应更低,但50 mg剂量的阿司匹林在急性期(1月内)应避免使用。
Objective To observe the effect of different doses of aspirin combined with clopidogrel on the elderly patients with unstable coronary artery disease. Methods 150 patients with unstable angina were randomly divided into group A,group B,group C,50 cases in each group. The three groups were given aspirin 50mg/d,75mg/d,100mg/d,each group were treated with clopidogrel 75mg/d for one year,and three groups all given the standard secondary prevention of coronary heart disease. The incidence of major adverse cardiovascular events and adverse events were observed in one month and one year after treatment. Results After one month＇s treatment,the incidence of major cardiovascular events in group A was higher than group B and group C（ P〈0. 05）,there was no significant difference between group B and group C（ P〉0. 05）. There was no significant difference in adverse reaction between the three groups（ P〉0. 05）. After one year follow-up,there were no significant difference among the major cardiovascular events between group A,B and C（ P〉0. 05）; The incidence of mild adverse reactions in group C was higher than that in group A and group B（ P〉0. 05）,however,there was no significant difference in the incidence of serious adverse reactions among three groups（ P〉0. 05）. Conclusion 50 mg and 75 mg of aspirin combined with clopidogrel is a safe and effective in elderly patients with unstable angina pectoris,and is less adverse reaction than100 mg standard dose,but 50 mg of aspirin should be avoided in the acute phase（ within one month）.
作者
周涛
刘强
ZHOU Tao LIU Qiang(Department of Cardiology, The People＇s Hospital of Anyue County,Si- chuan Province ,Anyue County 642350, Chin)
出处
《临床合理用药杂志》
2017年第10期1-2,共2页
Chinese Journal of Clinical Rational Drug Use
