摘要
目的:分析老年患者的ADR报告,了解老年人ADR的发生特点。方法:对2015年解放军ADR监测中心收到的5 411例老年人ADR报告回顾性调查,统计分析患者年龄、性别,怀疑药品数量、第一怀疑药品种类、累及系统/器官损害、ADR表现、ADR诱导期,关联性评价及转归等项目。结果:5 411例老年人ADR报告中,男女比例1.28∶1,与只有1个怀疑药品相比,多个怀疑药品中严重ADR报告的构成比更高(P<0.001)。ADR累及的系统/器官共6 104频次,排序前三位分别为胃肠疾病1 276频次(20.90%)、皮肤及皮肤附件损害1 110频次(18.18%)和全身性损害877频次(14.37%)。最常见的ADR症状表现为恶心753频次(9.88%),皮疹694频次(9.10%)。57.52%的ADR在用药后6 h内发生。结论:老年人ADR涉及药品品种多,累及多个系统/器官,应加强老年人用药的主动监测并对其用药风险进行评估,尽可能减少老年人ADR的发生。
Objective： To analyze adverse drug reactions（ADRs） occurred in elderly patients in order to study the characteristics of the elderly ADRs. Methods： A total of 5 411 elderly ADRs reports were included in 2015 in the database of PLA ADR monitoring center. The patients＇ age,gender,number of suspected drug,the first suspected drug types,the involved system/damaged organ,ADRs behavior,ADRs induction period,the relevance evaluated and outcome,reported type and occupation distributiion were analyzed statistically. Results： Among 5 411 elderly ADRs reports,ratio of males and females was 1. 28： 1. multiple suspected drug exposure experienced a high proportion of serious ADRs compared with the single suspected drug use（P〈0. 001）. Many systems/organs（6 104 frequencies） were involved in 5 411 ADRs reports,in which the most common is the gastrointestinal disorders（1 276 frequencies,20. 90%）,followed by the skin and appendages disorders（1 110 frequencies,18. 18%） and body as a whole-general disorders（877 frequencies,14. 37%）.Nausea（753 frequencies,9. 88%） and rash（694 frequencies,9. 10%） were the commonest symptoms. 57. 72% ADR occurred within 6 hours after administration. Conclusion： The elderly ADRs reports involved various drug categories and multiple systems/organs. In order to recognize and prevent ADRs in time,It was important to strengthen ADRs monitoring and assess medication risks in elderly patients to ensure their medication safety.
作者
贾王平
郭代红
张博
寇炜
王啸宇
胡鹏洲
Jia Wangping Guo Daihong Zhang Bo Kou Wei Wang Xiaoyu Hu Pengzhou(Department of Pharmaceutical Care, PLA General Hospital, Beijing 100853, China Outpatient Department, Academy of Armored Force Engineering)
出处
《药物流行病学杂志》
CAS
2017年第3期187-190,共4页
Chinese Journal of Pharmacoepidemiology
基金
2014年全军后勤科研重点项目(编号:BWS14R039)
关键词
老年人
药品不良反应
报告
用药安全
The elderly
Adverse drug reactions
Report
Medication safety
