摘要
目的观察依那普利联合氢氯噻嗪治疗小儿急性肾小球肾炎的临床疗效及安全性,为小儿急性肾小球肾炎患儿治疗方案选择提供参考。方法选取2015年1月-2016年2月医院收治的小儿急性肾小球肾炎患儿64例,将其随机分为观察组和对照组各32例。2组患儿均充分休息,观察组患儿采用依那普利联合氢氯噻嗪治疗,对照组患儿采用卡托普利片联合氢氯噻嗪片治疗,2组患儿均以10 d为1个疗程,比较2组患儿治疗过程中临床症状改善时间、临床疗效,统计2组患儿治疗过程中药物不良反应情况。结果观察组患儿浮肿消除时间、血压正常时间、蛋白尿正常时间及肉眼血尿消失时间均明显短于对照组患者(P<0.05)。治疗1个疗程后,观察组患儿临床总有效率93.75%明显高于对照组81.25%(P<0.05)。观察组不良反应发生率为3.12%明显低于对照组患儿的15.62%(P<0.05)。结论依那普利联合氢氯噻嗪治疗小儿急性肾小球肾患儿,可明显缩短患儿临床症状改善时间,提高临床治疗效果,且安全、可靠。
Objective To analyze the clinical efficacy and safety of enalapril combined with hydrochlorothiazide in treatment of children with acute glomerulonephritis,and provide a reference for the selection of treatment for children with acute glomerular nephritis. Methods 64 children with acute glomerulonephritis from January 2015 to February 2016 in hospital were randomly divided into observation group and control group,with 32 cases in each group. Two groups of children were full of rest,and control group were treated with captopril tablets combined with hydrochlorothiazide tablets treatment,observation group were treated with enalapril combined with hydrochlorothiazide treatment,two groups were in 10 days for a course of treatment,clinical symptom improvement time,clinical curative effect and drug adverse during the treatment were compared between two groups. Results Edema elimination time,the blood pressure returned to normal time,urine protein levels returned to normal time and gross hematuria disappeared time of observation group were all shorter than that of control group（ P〈0. 05）. After one course treatment,the clinical total effective rate of observation group（ 93. 75%） was higher than that of control group（ 81. 25%）（ P〈0. 05）. The adverse reaction rate of observation group（ 3. 12%） was lower than that of control group（ 15. 62%）（ P〈0. 05）. Conclusion Enalapril combined with hydrochlorothiazide in treatment of children with acute glomerulonephritis,can significantly reduce the clinical symptoms improved time,improve the clinical efficacy,and is safe and reliable.
出处
《临床合理用药杂志》
2017年第7期40-41,共2页
Chinese Journal of Clinical Rational Drug Use
