摘要
目的探讨早产儿血浆解脲脲原体菌血症(Uu-DNA阳性)和白细胞介素-6(IL-6)、白细胞介素-8(IL-8)浓度检测的意义。方法对75例胎龄<32周的极不成熟婴儿于生后不同时间分别采静脉血标本,测定血浆Uu-DNA拷贝数和IL-6、IL-8浓度,记录婴儿住院期间的病情变化。结果 9例(12%)在出生后1 h内血浆标本中检出Uu-DNA,其中7例Uu-DNA出现在宫内感染性肺炎患儿,以后时间所采标本均未检出Uu-DNA;Uu-DNA阳性患儿出生后1 h内血浆IL-6、IL-8浓度明显增高(P<0.05);Uu-DNA阳性患儿支气管肺发育不良发生率显著增高。结论极不成熟儿Uu-DNA阳性率占12%;Uu-DNA阳性患儿血浆炎性因子明显增高,支气管肺发育不良(BPD)发生也明显升高。
Objective To explore clinical significance of the measurements of plasma Ureaplasma urealyticum （Uu）-DNA copies and in-terleukin （IL-6 ） ,IL-8 concentration in very premature infants. Methods Venous blood samples were collected during lh ,3 d ,7 d ,14 d ,21 d of life from 75 consecutive singleton deliveries of very premature infants （gestational age 〈32 weeks） ,and plasma Uu-DNA copies and IL-6 ,IL-8 concentration were measured. Results 9 cases were detected plasma Uu-DNA copies from samples within 1 h,prevalence of Uu bacteremia was 12% （9/75）. Uu-DNA copies in all cases were undetected. Plasma IL-6 and IL-8 concentration of Uu bacteremic infants were significant higher compared with others from samples within 1 h （ P〈0. 05 ）. The incidence of bronchopulmonary dysplasia （ BPD） were significant higher in Uu bacteremic infants. Conclusions Prevalence of Uu bacteremia in very premature infants was 12 % . Uu bac-teremic infants had significant higher plasma proinflammatory cytokines level and the higher incidence of BPD（p〈0.05）.
出处
《安徽医药》
CAS
2017年第2期306-308,共3页
Anhui Medical and Pharmaceutical Journal
基金
深圳市科技研发资金项目(JCYJ20140415133340848)
