摘要
自人的印迹基因群11P15.5被发现以来,已被证明其与人体各种生理异常密切相关。而作为最早被鉴定的印记基因之一的非编码RNA分子H19(lncRNA H19),不仅由于其与Beckwith-Wiedemann综合征(BWS)、罗素因综合征(SRS)相关,而且H19能够派生miRNA675的印记基因,与多种肿瘤相关,可产生反义编码的lncRNA91H(功能尚不清楚)而引起学者关注。本文将首次从H19基因的印记属性、SNP变异、lncRNA属性及其可能的作用机制信号轴等方面就H19基因在肿瘤发生进程中的研究现状作一综述。
Since human imprinted genes in 11P15.5 was found, it had been proved that various human physiological abnormality associated with it. As one of the first identified imprinted non-coding RNA genes, more attention is paid to lncRNA H19 by many scholars not only because it＇s linked with Beckwith-Wiedemann syndrome （BWS） and Russell syndrome （SRS）, but also H19 gene is the only imprinted gene belonging to long non-coding RNA related with a variety of tumors which can also produce microRNA675 and lncRNA 91H coming from H19 gene antisense-coding. This paper will review possible mechanisms of H19 gene in tumorigenesis process and its research status in Cancer therapy from four aspects： imprinting feature, single nucleotide polymorphisms, lncRNA character and its possible action signal axis in cancer.
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2017年第2期224-230,共7页
Fudan University Journal of Medical Sciences
基金
国家自然科学基金(81572898,81402948)~~
