摘要
利用基因工程菌合成氨基酸是目前氨基酸生产研究的热点。本研究对基因工程菌生产氨基酸进行分析,为氨基酸工业化生产提供参考价值。阐述了氨基酸生产存在光学活性和效益差等现状以及固定化技术在应用生产中的价值,介绍基因工程定向诱变微生物发酵生产L-氨基酸的技术,分析基因工程菌培养中存在的问题,并对近些年来利用基因工程菌生产氨基酸的进展进行了综述。
Synthesis of amino acids by genetically engineered bacteria is a hotspot in the research of amino acid production. The synthesis of amino acids by genetically engineered bacteria was analyzed in this research, which provided reference for the industrial production of amino acids. This paper expounded the present situation of the optical activity and the poor benefit in the production of amino acids, and the value of the immobilization technology in the application. Also, we introduced genetic engineering directed mutagenesis microbial fermentation technology in the production of L-amino acid and analyzed the problems in the cultivation of genetically engineered bacteria. In this research, the progress of production for amino acids by genetically engineered bacteria in recent years was reviewed.
出处
《基因组学与应用生物学》
CAS
CSCD
北大核心
2017年第2期707-711,共5页
Genomics and Applied Biology
基金
安徽省高校自然科学研究重点项目(KJ2017A440)
宿州学院教授(博士)科研启动基金项目(2014jb06)
安徽省质量工程项目(2015zjjh034
2015ckjh108
2016jyxm1038)
宿州区域发展协同创新中心(特色种植业方向)开放课题(2015SZXTZXKFYB01)共同资助
关键词
基因工程菌
固定化
氨基酸
发酵
Genetically engineered bacteria, Immobilization, Amino acid, Fermentation
