摘要
目的对颅内动脉瘤并蛛网膜下腔出血潜伏肺部感染患者介入术后病原菌分布及其血液炎症因子C-反应蛋白(CRP)和炎症细胞进行研究,为临床相关诊断和治疗提供参考。方法医院介入手术室2011年6月-2015年12月,实施全麻颅内动脉瘤并蛛血弹簧圈介入栓塞术患者120例,随机分成Ⅰ组、Ⅱ组、对照组(Ⅲ组),各60例;采用全自动微生物鉴定仪对分离的病原菌进行鉴定,分析患者感染后CRP和炎症细胞的变化。结果 60例感染患者共分离98株病原菌,以革兰阴性菌为主,共63株占64.3%;Ⅰ组、Ⅱ组、Ⅲ组炎症因子和炎症细胞反应因子进行比较,差异均有统计学意义(P<0.05)。结论颅内动脉瘤并蛛血患者术后病原菌感染以革兰阴性菌为主,且感染患者的炎症因子和炎症细胞含量与术前蛛网膜下腔出血评分(Hunt-Hess Scale)和全麻通气方式相关。
OBJECTIVE To explore the pathogen distribution and blood inflammatory factor C-reactive protein （CRP） and inflammatory cells in patients with pulmonary infection combined with subarachnoid hemorrhage caused by cerebral aneurysm, so as to provide references for clinical diagnosis and treatment. METHODS A total of 120 cases of infected subarachnoid hemorrhage patients caused by cerebral aneurysm in our hospital from Jun. 2011 to Dec. 2015 were enrolled in this investigation. Patients were randomly divided into group Ⅰ , group Ⅱ , and control group （group Ⅲ ）, with 60 cases in each group. The isolated pathogens were identified by BE） PHOE- NiX TM100 （USA） equipment, changes of CRP and inflammatory ceils after infection were analyzed. RESULTS Totally 98 stains of pathogens were identified from 60 infected patients, which were mainly 63 strains of gram- negative bacteria, accounting for 64.3 %, There were significant differences in inflammatory factors and inflamma- tory cell response factors among group Ⅰ , group Ⅱ and group Ⅲ （P〈0.05）. CONCLUSION Subarachnoid hem- orrhage patients caused by cerebral aneurysm are suffered from gram-negative bacteria, and the levels of inflamma- tory factors and inflammatory cells in infected patients were correlated with preoperative subarachnoid hemorrhage score （Hunt-Hess Scale） and general anesthesia method.
作者
徐艳
冯秀荣
严仔敦
吴俊
杨文华
杨昌勇
廖大为
XU Yan FENG Xiu-rong YAN Zi-tcng WU Jun YANG Wen-hua YANG Chang-yong LIAO Da-wei(Tongren Peoplets Hospital, Tongren, Guizhou 554300, Chin)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2017年第7期1554-1557,共4页
Chinese Journal of Nosocomiology
基金
铜仁市科技计划基金资助项目[铜市科研(2014年)77-13号]
关键词
颅内动脉瘤并蛛血评分
病原菌分布
全麻通气方式
炎症反应
Cerebral aneurysm and subarachnoid hemorrhage score
Pathogen distribution
General ventilation an- esthesia method
Inflammatory reaction
