摘要
根据已有的具有抗肿瘤活性的咪唑[2,1-b]并-1,3,4-噻二唑类化合物的结构及其构效关系,以2-氨基-5-苯基-1,3,4-噻二唑和溴代乙酰乙酸乙酯为原料设计并合成了8个6-甲基-2-苯基咪唑[2,1-b]并-1,3,4-噻二唑-5-碳酰肼的腙类衍生物。通过~1HNMR、LC-MS、IR等方法对其结构进行了确证。
According to the structure and the structure-activity relationship of imidazo[ 2, 1-b ] [ 1,3,4 ] thiadiazole with antitu-mor activity, eight kinds novel hydrazone derivatives of 6-methyl-2-phenylimldazo [ 2,1 -b ] [ 1,3,4 ] thiadiazole-5-carhohydrazi-de were synthesized in the basis of 2-amino-5-phenyl-1,3,4-thiadiazole and bromination ethyl acetoacetate. The structures of the com- pounds were confirmed by 1HNMR,LC-MS and IR.
出处
《化学试剂》
CAS
北大核心
2017年第4期433-436,共4页
Chemical Reagents
