摘要
Whole-brain irradiation（WBI）,usually delivered in 25–30fractions to accumulate a total dose of 55–60 Gy,is commonly used for the treatment of primary tumors in the central nervous system（CNS）and brain metastases.With improved treatment techniques patients have prolonged overall survival,but are more likely to experience late adverse effects.
Whole-brain irradiation（WBI）,usually delivered in 25–30fractions to accumulate a total dose of 55–60 Gy,is commonly used for the treatment of primary tumors in the central nervous system（CNS）and brain metastases.With improved treatment techniques patients have prolonged overall survival,but are more likely to experience late adverse effects.
基金
supported by National Institutes of Health(NIH),grants:R01CA213441,R01CA133216
the Pediatric Brain Tumor Foundation Institute Grant
