摘要
目的:探讨参苓胃消胶囊对乳腺癌化疗期患者消化道反应及免疫功能的影响。方法:选取2011年6月至2015年7月期间我院确诊治疗的乳腺癌化疗期患者132例,依据随机分配原则分为观察组和对照组,每组66例,对照组患者在化疗期间给予阿扎司琼治疗(10 mg/次,1次/d,静脉输注至化疗后第7天),观察组患者给予参苓胃消胶囊治疗(2粒/次,3次/d,口服至化疗后第7天),采用流式细胞仪检测所有患者治疗前后CD3^+、CD4^+、CD8^+的水平,采用生活质量测定量表(QLQ-C30)评估所有患者治疗前、治疗后1 d、3 d、7 d的生活质量,统计分析所有患者消化道反应、免疫功能及其生活质量。结果:观察组患者消化道不良反应发生率明显低于对照组,差异有统计学意义(P<0.05);观察组患者治疗后CD3^+、CD4^+、CD4^+/CD8^+的水平明显优于对照组,差异有统计学意义(P<0.05);观察组患者治疗后1 d、3 d、7 d的QLQ-C30得分明显低于对照组,差异有统计学意义(P<0.05)。结论:参苓胃消胶囊可有效减少乳腺癌化疗期患者消化道不良反应的发生,增强患者的免疫功能,有利于提高患者生活质量及临床疗效,值得临床作进一步推广。
Objective： To discuss the effect of Ginseng and Poria Stomach Capsule on gastrointestinal reaction and immune function in patients with breast cancer receiving chemotherapy. Methods： A total of 132 patients with breast cancer were selected and divided randomly into capsule group and control group,66 in each group. The control group patients received Azasetron（10 mg/time,1/d,intravenous infusion given for 7 days after chemotherapy）,capsule group patients received Ginseng and Poria Stomach Capsule（2pills/time,3 times/d,to oral taken for 7 days after chemotherapy）. The CD3,CD4,CD8 levels were evaluated by flow cytometer.The（QLQ C30） scale was used to assess quality of life after 1,3,7 d＇ s treatment of all patients. Results： The gastrointestinal adverse reactions of the capsule group were significantly lower than the control group（P 〈0. 05）; CD3,CD4,CD4/CD8 levels of the capsule group were significantly better than control group（P 〈0. 05）; QLQ C30 score of the capsule group after 1,3,7 d＇ s treatment were significantly lower than the control group（P 〈0. 05）. Conclusion： Ginseng and Poria Stomach Capsule can effectively reduce the gastrointestinal adverse reaction of breast cancer patients in chemotherapy period and enhance the immunity function of the patients,as well as improve patient＇s quality of life and clinical curative effect.
出处
《世界中医药》
CAS
2016年第10期1978-1980,1985,共4页
World Chinese Medicine
基金
河北省中医药管理局科研计划项目(编号:2011156)
关键词
参苓胃消胶囊
乳腺癌
免疫功能
消化道反应
Ginseng and Poria Stomach Capsule
Breast cancer
Immune function
Gastrointestinal reaction
