摘要
目的:观察华蟾素胶囊联合化疗治疗中晚期胃癌疗效及对患者生活质量、不良反应的影响。方法:将符合入选标准的60例患者随机分为治疗组和对照组,对照组采用FOLFOX4方案化疗和对症支持治疗,治疗组在上述治疗的基础上加用华蟾素胶囊,比较2组患者近期客观有效率、稳定率、生活质量和不良反应。结果:治疗组近期客观有效率明显高于对照组,差异有统计学意义(P<0.05),治疗组治疗后生活质量及不良反应指标明显优于对照组,差异有统计学意义(P<0.05)。结论:华蟾素胶囊联合化疗药物和单纯化疗药物对中晚期胃癌患者均有疗效,并可提高患者生活质量,减轻化疗不良反应,但前者明显优于后者。
Objective： To observe the effects of Huachansu capsule combined with chemotherapy in the treatment of advanced gastric cancer,as well as its effect on patients＇ life quality and its adverse reaction. Methods： Sixty cases meeting the inclusion criteria were randomly divided into the treatment group and control group. The control group was treated by FOLFOX4 regimen chemotherapy and supportive treatment,and the treatment group by those plus Huachansu capsule. Short-term objective efficiency,stable rate,quality of life and adverse reaction were compared between the two groups. Results： After treatment,short-term objective effective rate of the treatment group was significantly higher than that of the control group（ P〈 0. 05）. The quality of life and adverse reaction index of the treatment group were obviously superior to that of the control group（ P 〈0. 05）. Conclusion： Both Huachansu capsule combined with chemotherapy and the single chemotherapy therapy have curative effects in treating advanced gastric cancer. However,Huachansu capsule combined with chemotherapy could better improve patients＇ quality of life,and reduce adverse reaction of chemotherapy.
出处
《世界中医药》
CAS
2016年第7期1212-1214,共3页
World Chinese Medicine
基金
国家自然科学基金项目--基于"肺与大肠相表里"理论的肺肠同源发生的分子生物学机制研究(编号:81273614)
北京市自然科学基金项目--基于相合脏腑同源发生认识和功能相关理论的心与小肠同源发生的分子生物学机制研究(编号:7152070)
关键词
中晚期胃癌
中西医结合疗法
华蟾素胶囊
临床观察
Advanced gastric cancer
Chinese medicine
Huachansu capsule
Clinical observation
