摘要
[目的]观察六味地黄丸与润肠丸恶性肿瘤治疗吗啡后便秘疗效。[方法]使用随机平行对照方法,将60例住院患者按就诊顺序号方法简单随机分两组。对照组30例聚乙二醇4000散,20g/d,顿服,饭前30min服用。治疗组30例六味地黄丸、润肠丸,统一煎制,每日早中晚饭后半小时各服1次,1袋/次,150m L/袋。连续治疗2周为1疗程。观测临床症状、排便间隔、排便时间、排便难度、便质、兼症缓解情况、疼痛分级、不良反应。连续治疗1疗程,判定疗效。[结果]治疗组痊愈11例,显效6例,有效6例,无效6例,总有效率76.70%;对照组痊愈7例,显效10例,有效5例,无效8例,总有效率73.30%;治疗组疗效优于对照组(P>0.05)。缩短排便时间、降低排便难度、改善便质减少分值治疗组明显优于对照组(P<0.05),排便间隔减少分值两组间无明显差异(P>0.05)。兼症缓解情况治疗组优于对照组(P<0.05)。疼痛评分两组间无明显差异(P>0.05)。[结论]六味地黄丸与润肠丸治疗恶性肿瘤吗啡后便秘,疗效满意,无严重不良反应,与聚乙二醇4000散治疗具有等效性,缩短排便时间、降低排便难度等有明显优势,可更快改善患者生活质量,值得推广。
[Objective] To observe the clinical effect of combination decoction of Liuwei Dihuang pill and Runchang pill on treating constipation which caused by Morphine. [Method] 60 hospitalized patients were divided into two groups randomly according to the ID number, and each group has 30 cases. Macrogol 4000 powderon（20g/d） was given to each one of the 30 cases of the control group once orally 30 minutes before meal. Combination decoction which decocted uniformly by decoction room（one bag each time, 150 ml/bag） of Liuwei Dihuang pill and Runchang pill was given to each one of the 30 cases of the treatment group orally 30 minutes after breakfast, lunch, and dinner everyday. Two weeks was a treating course. To observe the clinical symptoms, defecating time interval, defecating time, defecating difficulty level, stool quality, accompanied symptom remission, pain grade and adverse reaction. Continuously treating one course, then judge therapeutic effect. [Result] In treatment group, 11 cases recovered, 6 cases significantly improved,6cases ineffective, and the total effective rate of this group was 76.70%. In control group, 7 cases recovered, 10 cases significantly improved, 5 cases effective, 8 cases ineffective, and the total effective rate of this group was 73.30%. The treatment group was significantly superior to the control group（P〈0.05）. The treatment group was superior to the control group in shorten defecation time, reduce the defecating difficulty, improve stool quality and remit accompanied symptom（P〈0.05）. No significant differences in defecating time interval and pain grade between the two groups（P〈0.05）. [Conclusion] The combination decoction of Liuwei Dihuang pill and Runchang pill has more satisfactory clinical effect compare with Macrogol 4000 powderon,but has no serious adverse reaction, so it is worth to be popularized and applied.
出处
《实用中医内科杂志》
2017年第2期28-30,共3页
Journal of Practical Traditional Chinese Internal Medicine
关键词
恶性肿瘤吗啡后便秘
六味地黄丸
润肠丸
聚乙二醇4000散
大便性状
中医药治疗
随机平行对照研究
malignant tumor after morphine constipation
rehmannia six
Fang Runchang pill
polyethylene glycol 4000 powder
stool
Chinese medicine therapy
randomized controlled study
