摘要
目的探究降钙素原的测定对间质性肺疾病合并感染的临床诊断价值。方法患者入院后行胸部CT、血常规、血气分析、血清CRP、血清PCT、痰标本行病原学等检查。根据患者的临床表现、检查结果、治疗反应等将入选病例分为间质性肺疾病合并感染组,非感染性间质性肺疾病组。结果共有77例患者入选,被选入间质性肺疾病合并感染组有46例,被选入非感染性间质性肺疾病组有31例。间质性肺疾病合并感染患者与非感染性间质性肺疾病患者相比,血清PCT[(0.70±1.32)ng/m L vs(0.04±0.01)ng/m L,P<0.01];诊断间质性肺疾病合并感染的ROC曲线下面积PCT 0.918±0.033,且PCT在最佳截断值时的灵敏度为87%,特异度为90.3%;结论与其他常用炎性指标相比,降钙素原的测定可明显提高间质性肺疾病合并感染诊断的准确率,还可指导临床抗生素的合理使用。
Objective To investigate the clinical value of procalciton in interstitial lung disease with co-in- fection. Methods Patients were given CT chest, general blood test, blood gas analysis, CRP, PCT and remaining pathogenic examination of sputum specimens, and they were divided into the co-infection group and the non-infection group according to their clinical manifestations, examination results and response to treatment. Results 77 patients were enrolled. There were 46 patients in the co-infection group and 31 cases in the non-infection group. The PCT lev- el was higher in the co-infection group than in the non-infection group [ （0. 70 ± 1.32） ng/mL vs （0.04±0.01 ） ng/ mL, P 〈 0. 01 ]. In the diagnosis of interstitial lung disease with co-infection, AUC value was 0. 918 ±0. 033 for PCT. The sensitivity of PCT was 87% at the optimum cut-off value and its specificity was 90. 3%. Conclusion Compared with other common inflammatory markers, the measurement of procalciton could develop diagnostic accura- cy of interstitial lung disease with co-infection, with high sensitivity and specificity. Meanwhile, it can guide the ra- tional clinical use of antibiotics.
出处
《临床肺科杂志》
2017年第5期884-887,共4页
Journal of Clinical Pulmonary Medicine
关键词
间质性肺疾病
降钙素原
感染
interstitial lung disease
procalcitonin
infection
