摘要
组织干细胞是组织器官稳态维持和损伤修复或再生的结构基础。伴随着年龄的增加,组织干细胞的数量、增殖和分化等功能及其所处微环境发生改变,从而使得老年个体再生修复功能降低或异常。此外,组织干细胞的衰老与老年个体衰老相关疾病的发生有着密切的关系。该文拟介绍几种目前比较明确的组织干细胞在老年个体中发生改变的基本特征及其发生机制,旨在为正确理解老年组织机能低下提供重要的理论基础,并希望能够建立有效可行的延缓或逆转组织干细胞衰老的途径以提高老年人群的生活质量。
Tissue-specific stem cells play a vital role in tissue homeostasis and regeneration. Aging tissues experiencing a progressive decline in regenerative function is considered as changes in number of tissue-specific stem cells, stem cell niches, proliferative and differentiation capacities. Moreover, the age-dependent diseases may be directly associated with these dysfunctional stem cells and their niches. Here, we explore the effects of aging on several reported tissue-specific stem cells in different tissues and molecular mechanisms underlying stem cells age. With this increased understanding, it is feasible to design and test interventions that delay or reversal tissue-specific stem cell aging and improve both health and lifespan.
出处
《中国细胞生物学学报》
CAS
CSCD
2017年第2期223-231,共9页
Chinese Journal of Cell Biology
基金
上海市科研计划项目(批准号:15JC1403900)
国家自然科学基金项目(批准号:31601101)资助的课题~~
关键词
组织干细胞
衰老
干细胞巢
tissue-specific stem cells
aging
stem cell niche
