摘要
目的:探讨西甲硅油乳剂联合枯草杆菌肠球菌二联活菌肠溶胶囊(美常安)在肠易激综合征(IBS)治疗中的临床效果。方法:将2014年1月至2015年10月收治的180例IBS患者随机分为西甲硅油乳剂联合枯草杆菌肠球菌二联活菌治疗组92例和单药枯草杆菌肠球菌二联活菌治疗对照组88例,治疗4周后随访观察两组患者的治疗总有效率、不同胃肠症状的治疗有效率,以及不同型IBS患者的胃肠症状评分。结果:IBS治疗组的治疗总有效率为88.0%,明显高于对照组70.5%(P<0.05)。治疗4周后腹胀和排便次数改善的有效率分别为94.6%和78.3%明显高于对照组的77.3%和60.2%(P<0.05),但两组在腹痛和排便性状改善方面比较无明显差异(P>0.05)。对两组不同胃肠症状评分结果:显示同组同型IBS治疗4周后胃肠症状评分均明显低于治疗前(P<0.05)治疗有效。但两组同型IBS患者的治疗后胃肠症状评分比较时,仅在便秘型IBS患者差异明显(P<0.05)。结论:西甲硅油乳剂联合枯草杆菌二联活菌肠溶胶囊对肠易激综合征(IBS)患者治疗有效,对缓解腹胀和改善排便次数上治疗效果尤为明显,对IBS便秘型患者的胃肠症状恢复疗效最佳。
Objective：To observe the clinical effect of simethicone emulsion combined with Bacillus subtilis in the treatment of patients with irritable bowel syndrome（IBS）.Methods：A total of 180 patients with IBS during January 2014 and October 2015 were randomly divided into simethicone emulsion combined with Bacillus subtilis group（treatment group,n=92） and single Bacillus subtilis group（control group,n=88）.All patients were treated for 4 weeks and were followed up to observe the symptoms of gastrointestinal tract.Then the total effective rate of treatment,the respective effective rate of different gastrointestinal symptoms and the Gastrointestinal Symptom Rating Scale（GSRS） were analyzed in different types of IBS patients before and 4 weeks after the treatment.Results：The total efficiency of patients in treatment group after 4 weeks of treatment was 88.0%,significantly higher than that of the control group,the total efficiency of 70.5%（P〈0.05）.The treatment efficiency of abdominal distension and stool frequency in treatment group were respectively 94.6%and 78.3%,significantly higher than that of the control group of 77.3%and 60.2%（P〈0.05）,but the abdominal pain and stool characteristics change in two groups had no significant difference（P〉0.05）.GSRS of same type IBS patients in the same group after 4 weeks of treatment were significantly lower than that of IBS patients before treatment（P〈0.05）,and the treatment was quite effective.However,in four groups of patients with different types of IBS in 4 weeks after the treatment,only GSRS of patients with IBS-constipation has significant difference（P〈0.05）.Conclusions：Simethicone emulsion combined with Bacillus subtilis is effective for the patients with irritable bowel syndrome（IBS）,which can particularly alleviate pain and improve the stool frequency,Gastrointestinal symptom recovery of the patients with constipation has the best effect among different type IBS patients.
作者
王少鑫
崔立红
弓三东
李超
于兰
罗哲
WANG Shao-xin CUI Li-hong GONG San-dong LI Chao YU Lan LUO Zhe(Department of Gastroenterology, Navy General Hospital, Beijing, 100048, China)
出处
《现代生物医学进展》
CAS
2017年第6期1102-1105,共4页
Progress in Modern Biomedicine
基金
吴阶平临床科研专项资助基金项目(320.6750.13175)
海军后勤科研计划课题(CHJ12J027)
