摘要
目的:研究甲硝唑药膜联合盐酸米诺环素软膏治疗牙周病的临床疗效。方法:选择2014年1月~2016年1月在我院进行诊治的牙周病患者80例,随机分为两组。观察组采用甲硝唑药膜联合盐酸米诺环素软膏治疗治疗,对照组采用甲硝唑药膜治疗。观察并比较两组的疗效,牙周附着指数、牙菌斑指数、牙龈指数、牙齿松动度和白介素-6、白介素-8和肿瘤坏死因子的水平。结果:治疗4周后,观察组的治疗有效率为95.0%,明显高于对照组的90.0%(P<0.05);治疗后两组的牙周附着指数、牙菌斑指数、牙龈指数和牙齿松动度均较治疗前明显降低(P<0.05),且观察组的降低程度明显优于对照组(P<0.05);治疗后两组的肿瘤坏死因子、白介素-6和白介素-8均较治疗前明显降低(P<0.05),且观察组的降低程度明显优于对照组(P<0.05);两组间丘疹、恶心、胃肠道反应和失眠的发生情况相比无明显差异(P>0.05);观察组的复发率为2.5%,明显低于对照组的7.5%(P<0.05)。结论:甲硝唑药膜联合盐酸米诺环素软膏能增强对牙周病各种致病菌的抑制作用,提高临床疗效,改善牙周状况和炎症状态,不良反应少,且复发率低,值得推广应用。
Objective： To investigate the clinical effect of metronidazole membrane combined with minocycline ointment on periodontal disease. Methods： 80 cases of patients with periodontal disease in our hospital from January 2014 to January 2016 were select and divided into observation group and control group. The patients in the observation group were treated with metronidazole membrane combined with minocycline ointment, and the patients in the control group were adopted metronidazole membrane. The curative effect,periodontal attachment index, plaque index, gingival index, tooth mobility degree and the levels of serum IL-2, IL-6, IL-8 and TNF were compared between the two groups. Results： After 4 weeks, The curative effect of the observation group（95.0%） was significantly higher than that of the control group（90.0%）（P〈0.05）; the periodontal attachment index, plaque index, gingival indexand tooth mobility degree and the levels of serum IL-2, IL-6, IL-8 and TNF in two groups were all were significantly decreased（P〈0.05）, and the reduce degree of observation group was more obviously than that of the control group（P〈0.05）; no difference was found between the two groups as to pimples, nausea and gastrointestinal reaction and insomnia（P〉0.05）; the recurrence rate of the observation group（2.5%）was significantly lower than that of the control group（7.5%）. Conclusions： Metronidazole membrane combined with minocycline ointment can enhance inhibition of periodontal pathogens, and improve the clinical effect, the periodontal condition and state of inflammation, and has less adverse reactions, low recurrence rate, worthy of application.
出处
《现代生物医学进展》
CAS
2017年第4期746-749,共4页
Progress in Modern Biomedicine
关键词
甲硝唑药膜
盐酸米诺环素软膏
牙周病
Metronidazole membrane
Minocycline ointment
Periodontal disease
