摘要
目的根据上海地区气传花粉监测数据,对上海闵行地区季节性变应性鼻炎患者在春季进行预防性治疗的临床疗效观察。方法选择上海闵行地区2014年10月~2015年4月耳鼻咽喉科门诊就诊的季节性对花粉过敏的变应性鼻炎患者,随机分为两组:预防治疗组44例,正常治疗组45例。两组患者均应用抗组胺药物咪唑斯汀10 mg口服,1次/d,预防治疗组根据上海地区气传花粉检测数据,从花粉高峰期前2周开始应用咪唑斯汀持续用药一直到花粉高峰期结束;正常治疗组则选择在花粉高峰期伊始就医的患者进行用药;治疗期间每两周分别记录视觉模拟评分以及医学结局研究简表36项健康调查。结果在闵行区域4月花粉高峰期为时间段,预防治疗组的VAS评分在鼻痒、鼻塞、睡眠、工作影响和整体舒适感方面的指标均优于正常对照组,差异具有统计学意义(P均<0.01)。而SF-36生活质量量表也显示,在与变应性鼻炎最相关的RP(生理职能)与RE(情感职能)两个维度中,预防治疗组得分均高于正常治疗组,并在整个花粉高峰期均保持一个较好的生活质量。结论根据气象数据及时给予预防性用药对于季节性变应性鼻炎的发作均具有明显的抑制作用,应加强患者根据气象相关预报增强预防意识。
Objective To observe the clinical effect of antihistamines for preventive treatment of seasonal allergic rhinitis in Shanghai Miuhang district. Methods A total of 89 outpatients with seasonal allergic rhinitis from Oct 2014 to Apr 2015 were recruited and randomly divided into preventive treatment group （n = 44 ） and standard treatment group （n = 45 ）. For the patients of the preventive treatment group, oral administration of mizolastine （ once a day with a daily dosage of 10 rag） started 2 weeks before the peak of fluttered pollen and lasted to the end of pollen season. As tot the patients of the standard treatment group, oral administration of mizolastine （ once a day with a daily dosage of 10 mg） started once they came to clinic during the peak of fluttered pollen and lasted to the end of pollen season. Treatment effect of both groups was recorded every two weeks by visual analog scale （VAS） and the medical outcomes study 36 items short form health survey （SF-36）. Results Analyses of VAS scores showed that the score improvements of nasal itching, nasal congestion, sleep, impact on work and holistic comfort in the preventive treatment group were better than those of the standard group（ all P 〈 0.01 ）. As for the patients＇condition improvement in the aspects of SF-36, the preventive treatment group was better than the standard group on two dimensions of RP and RE. The patients of the preventive treatment group could maintain better quality of life throughout the peak of fluttered pollen. Conclusion Preventive and persistent medication can obviously inhibit seasonal allergic rhinitis in Shanghai Minhang district.
出处
《中国耳鼻咽喉颅底外科杂志》
CAS
2017年第1期12-15,共4页
Chinese Journal of Otorhinolaryngology-skull Base Surgery
关键词
变应性鼻炎
咪唑斯汀
闵行地区
预防性治疗
Rhinitis, allergic
Mizolastine
Minhang district
Preventive treatment
