摘要
癌症相关脑梗死的发病机制可能与脑梗死的常见发病机制不同。癌症可以通过侵犯邻近心脏、血管直接导致脑梗死的发生。癌症也可以引起非细菌性血栓性心内膜炎、癌症相关血液高凝状态等,血栓脱落及血流中微小栓子形成最终导致脑梗死的发生。此外,针对癌症的治疗也可以导致患者脑梗死的发生风险升高。外周血中性粒细胞胞外诱捕网的升高有望成为癌症相关脑梗死的生物标志物。由于多数患者外周血D二聚体水平升高,抗凝和抗血小板的药物可能会减少癌症相关脑梗死发生风险。
The pathogenesis of cancer related stroke might differ from conventional ischemic stroke. Cancer can directly invade adjacent organs and blood vessels,which can directly lead to ischemic stroke. Cancer can lead to non-bacterial thrombotic endocarditis,cause cancer related hypercoagulability,and finally lead to ischemic stroke. And treatments of cancer can also increase the risk of ischemic stroke. The increasing level of neutrophil extracellular traps might be one of the specific biomarkers of cancer related ischemic stroke. Anticoagulation and antiplatelet drugs may probably reduce the risk of cancer related ischemic stroke.
出处
《医学综述》
2017年第6期1109-1112,1117,共5页
Medical Recapitulate
基金
国家自然科学基金(30860088
81260186)
广西自然科学基金(桂科自0832134
桂科自0991149
2015GXNSFAA139228)
