摘要
目的探究地奥司明和尼美舒利联用治疗膝关节创伤性滑膜炎的临床疗效。方法选取解放军第425医院收治的符合诊断标准和本研究要求的患者60名,分为3组,联合组、尼美舒利组、地奥司明组各20例,联合组给予地奥司明和尼美舒利联合治疗,尼美舒利组予以尼美舒利治疗,地奥司明组予以地奥司明治疗,均以14 d为1疗程。分别对治疗前后各组进行膝关节VAS、AKS评分、肿胀程度评级,并根据以上数据进行疗效判定。结果经过14 d治疗后,3组患者治疗后膝关节肿胀、疼痛程度均较前有不同程度改善,治疗前后差异明显(P<0.05),且联合组的前后差异幅度更大(P<0.05),有效率更高。结论地奥司明和尼美舒利分别对创伤性滑膜炎治疗均有一定疗效,但单独使用不及两者联合治疗疗效显著。联合使用可更加明显的缓解患者的疼痛,阻止病情进展,减轻炎症反应,稳定病情,达到满意的治疗效果。
Objective To observe the clinical curative effect of diosmin combined with nimesulide in treatment of drugs for the traumatic synovitis ofin knee joint. Methods Sixty patients the People＇s Liberation Army 425 Hospital diagnosis standard and the requirements in this study were averagely and randomly divided into combination group, nimesulide group and diosmin group, the patients in combination group were given diosmin and nimesulide treatment, the patients in nimesulide group were given nimesulide treatment, diosmin group were given diosmin treatment. The course of treatment was 14 d. Then score knee joint VAS, AKS rating, and swelling degree in each group before and after the treatment. Results After treatment, the patients with knee joint swelling, pain degree are improved, the difference before and after treatment has statistical significance （P 〈 0.05）, meanwhile differences in the combination group were larger than the other two groups （P 〈 0.05）. Conclusion The drugs ofnimesulide and diosmin for the treatment of traumatic synovitis respectively have certain effect, but the combined treatment curative effect is remarkable than used alone. Combination medication can be more obviously relieving the pain of patients and prevent disease progression, reduce inflammation which achieved a satisfactory therapeutic effect.
出处
《药物评价研究》
CAS
2017年第1期115-118,共4页
Drug Evaluation Research
关键词
膝关节
创伤性滑膜炎
非甾体抗炎药
尼美舒利
地奥司明
knee joint
traumatic synovitis
non-steroidal anti-inflammatory drugs
nimesulide
diosmin
