摘要
目的:运用"中医传承辅助平台(V2.5)",分析"疾病-证候-治法-中药"之间的关系,探讨丁学屏教授诊治糖尿病及其慢性并发症的临证经验及用药规律,总结丁学屏教授学术经验。方法:通过临床医案采集,结合软件的分析系统,采用频次统计法,统计得出医案症状、证候、治法出现频次,使用中药性味归经频次;采用关联规则分析法、聚类分析法、改进的互信息法、复杂系统熵聚类、无监督的熵层次聚类等高级数据挖掘方法,统计得出处方中药物组合使用频次及药物之间的关联规则。结果:本研究对39例糖尿病阴虚热盛证进行分析,高频药物有地骨皮、黄连、山药、地黄、知母等,药物组合有桑叶、黄连,桑白皮、黄连,地黄、桑叶、黄连等。对29例糖尿病气阴两虚证进行分析,高频药物有黄连、山药、地黄、地骨皮、知母等,药物组合有黄连、地骨皮,地黄、地骨皮、黄连,地骨皮、山药、黄连等。结论:辨治糖尿病,兼顾"本虚标实",治拟"清热、滋阴"并举,多用甘寒生津之品清热救液。
Objective： Analyzing the ＇ disease-syndrome-treatment-medicine＇ experience of professor Ding for diabetes and its chronic complications by using Traditional Chinese Medicine （TCM） Inheritance Support System （V2.5）. By analyzing the data, we summarize the Professor Ding＇s academic experience. Method： Through collecting the standard clinical cases, combined with the software analysis system, we analyze the composing principles by using datamining methods such as frequency statistics, revised mutual information,association rules analysis, cluster analysis, improvement of mutual information, complex system entropy clustering, unsupervised hierarchical clustering entropy and so on. Result： Characteristics of simple diabetes. Based on the analysis of 39 cases of simple diabetic ＇ Yin deficiency and heat Syndrome＇ , the highest-frequency used drugs were Lycii Cortex, Rhizoma Coptidis, Dioscoreae Rhizoma, Rehmanniae Radix, Anemarrhenae Rhizoma and so on. The highest-frequency used drug combinations were Mori Folium, Rhizoma Coptidis; Mori Cortex, Rhizoma Coptidis; Rehmanniae Radix, Mori Folium, Rhizoma Coptidis and so on. Based on the analysis of 29 cases of ＇ Qi and Yin deficiency syndrome＇ , the highest-frequency used drugs were Rhizoma Coptidis, Dioscoreae Rhizoma, Rehmanniae Radix, Lycii Cortex, Anemarrhenae Rhizoma and so on. The highest-frequency used drug combinations were Rehmanniae Radix, Lycii Cortex; Rehmanniae radix, Lycii Cortex, Rhizoma Coptidis; Lycii Cortex, Dioscoreae Rhizoma, Rhizoma Coptidisand so on. Conclusion： Treating simple diabetes focus on the ＇ asthenia in origin and asthenia in superficiality＇ , ＇ remove heat and nourish Yin is important＇ , we often use herbs which aresweet-flavored and cold-natured.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2017年第7期198-205,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家科技支撑计划项目(2012BAI41B05)
国家自然科学基金项目(81503552)
上海市中医药事业发展三年行动计划项目(ZY3-CCCX-2-1003)
上海市中医临床重点实验室项目(14DZ2273200)
关键词
丁学屏
糖尿病
中医传承辅助平台(V2.5)
数据挖掘
学术经验传承
用药规律
DING Xue-ping
diabetes mellitus
Traditional Chinese Medicine （TCM） Inheritance Support System
data mining
academic experience inheritance
drug laws
