摘要
耐多药结核病（MDR-TB）是目前临床结核病治疗的难题之一,快速检出耐多药的结核分枝杆菌（MTB）,指导临床选择有效抗结核药物,制定合理的化疗方案,是控制MDR-TB的关键.目前抗结核药物的药物敏感性试验（简称“药敏试验”）方法主要有下列三类：一是建立在细菌生长基础上的药敏试验方法;二是建立在基因多态性分析基础上的分子药敏试验方法;三是建立在耐药MTB特异组分基础上的色谱、质谱方法.作者概要地介绍了MTB的药敏试验方法,以及联合应用现有药敏检测技术以提高临床对MDR-TB的诊断率.
At present,multidrug-resistant tuberculosis （MDR-TB） is one of the difficult problems in clinical treatment of tuberculosis.The rapid detection of drug resistant Mycobacterium tuberculosis （MTB）,to guide the clini cal selection of effective anti-TB drugs,to determine reasonable chemotherapy regimen,were the key points to control MDR-TB.There are mainly three kinds of anti-TB drug sensitivity test methods as follow：（1） the anti-TB drug sensitivity test methods based on bacterial growth;（2） the molecular drug sensitivity test methods based on the gene polymorphism analyses;（3） the chromatography and mass spectrometry methods based on specific components of drug-resistant MTB.This paper briefly introduces the MTB drug sensitivity test methods,and the combined use of the existing drug sensitivity testing techniques,to improve the clinical diagnosis rate of MDR-TB.
作者
吴雪琼
张俊仙
WU Xue-qiong ZHANG Jun-xian(Institute for Tuberculosis Research, Army Tuberculosis Prevention and Control Key Laboratory, Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment, the 309th Hospital of Chinese People＇s Liberation Army, Beijing 100091, China)
出处
《中国防痨杂志》
CAS
2017年第3期222-225,共4页
Chinese Journal of Antituberculosis
关键词
分枝杆菌
结核
药物耐受性
微生物敏感性试验
Mycobacterium tuberculosis
Drug tolerance
Microbial sensitivity tests
