摘要
目的探讨新活素（冻干重组人脑利钠肽）对慢性心力衰竭合并糖尿病的老年患者心率变异性的影响及其有效性、安全性。方法将确诊为慢性心力衰竭合并2型糖尿病的60例老年患者随机平均分为2组：对照组根据慢性心力衰竭和糖尿病指南行基础治疗和有效的控制血糖治疗；干预组为基础治疗联合静脉滴注新活素。观察两组患者的心率变异性变化和心衰的缓解程度、左室舒张末内径、左室射血分数、6rain步行试验、N端B型钠尿肽前体、24h尿量等变化。结果干预组胸闷气短程度改善情况及左室舒张末内径、左室射血分数、N端B型钠尿肽前体明显好于对照组；治疗后6min步行距离干预组和对照组分别为（468±123）m和（390±124）m；尿量干预组和对照组分别为2680ml和2130ml，两组差异有统计学意义（P〈0．05）；两组患者的心率变异性均降低，治疗后频域功率24h、SDANN（每5minRR间期平均值标准差）干预组分别为（2244±1480）ms、（42．5±16．1）ms，而对照组分别为（2006±1632）ms、（32．2±18．6）ms，两组差异有统计学意义（P〈0．05）。两组无不良反应发生。结论新活素能够有效地改善老年慢性心力衰竭合并糖尿病患者的症状，修复患者自主神经损伤，且安全、有效。
Objective To observe frozen rhBNP on chronic heart failure complicated with diabetes in elderly patients with heart rate variability of the impact and effectiveness and safety. Methods Diagnosed 60 cases of type 2 diabetes in elderly patients were randomly divided into chronic heart failure combined for two groups： the control group according to the chronic heart failure and diabetes guidelines based therapy and effectively control blood glucose treatment, the intervention group on the basis of the treatment combined static and new live prime, watch of the patients in the two groups, heart rate variability （HRV） change and heart failure relief degree, left ventricular diastolic diameter （LVDD）, left ventricular ejection fraction, 6 minutes walk test, N terminal pro-B- type natriuretic peptide precursor, 24 hours urine volume changes. Results Degree of intervention group chest condition improved and left ventricular end-dlastolic diameter, left ventricular ejection fraction, n-terminal b-type natriuretic peptide precursor is much better than the control group; 6 min walking distance intervention group and control group after treatment（468±123 ）m, respectively（390±124）m. Urine intervention group and control group respectively for 2680 ml, 2130 ml, differences between the two groups was statistically significant （P〈0.05）. Two groups of patients with heart rate variability are lower, frequency domain power 24 h after treatment, SDANN（RR period average standard deviation between every 5 minutes） intervention group（2244±1480）ms, respectively（42.5± 16.1）ms, and the control group, respectively （2006±1632）ms, （32.2：t：lS.6）ms, ms differences between the two groups was statistically significant（P〈0.05）. Two groups have no adverse reaction occurred. Conclusion The new active elements can effectively improve the elderly patients with chronic heart failure and diabetes symptoms, can repair the patients with autonomic nervous damage, safe and effective.
出处
《中国心血管病研究》
CAS
2017年第2期169-173,共5页
Chinese Journal of Cardiovascular Research
关键词
新活素
慢性心力衰竭
2型糖尿病
心率变异性
Recombinant human brain natriuretic
Chronic heart failure
Type 2 diabetes mellitus
Heart rate variability
