摘要
目的 探讨地奥司明片内服对改良肛裂切除术后疼痛及创面愈合的影响。方法 选取2015年1月～2016年7月绍兴市人民医院肛肠外科收治的符合纳入标准且行改良肛裂切除术患者98例,按随机数字表法分为对照组和研究组,每组各49例,对照组给予常规术后治疗;研究组在常规术后治疗基础上给予地奥司明片治疗,2组共治疗7d为一疗程,于治疗前后观察并记录创面疼痛程度、创面宽度及创面愈合状况,采血测定血清炎症因子变化,比较临床疗效及并发症。结果 治疗后,2组创面疼痛程度、创面宽度及创面愈合评分均降低,血清肿瘤坏死因子-α（tumor necrosis factor-α,TNF-α）、干扰素（interferon-γ,IFN-γ）、白细胞介素-6（Interleukin-6,IL-6）含量均降低,差异有统计学意义（P〈0.05）;与对照组比较,研究组创面疼痛程度、创面宽度及创面愈合评分较低,血清TNF-α、IFN-γ、IL-6含量较低,平均愈合时间、肉芽生长时间及祛腐时间较短,差异有统计学意义（P〈0.05）;研究组有效率为91.83%,高于对照组有效率75.51%,差异有统计学意义（P〈0.05）;所有患者均获得随访,无病例脱落现象,2组间不良反应发生率比较,差异无统计学意义。结论 地奥司明片内服对改良肛裂切除术后创面愈合具有促进作用,降低炎症指标,缓解疼痛状况。
Objective To investigate the effect of diosmin on the pain and wound healing after modified anal fissure resection .Methods 98 patients from January 2015 to July 2016 in our hospital who were admitted to meet the inclusion criteria and improved anal fissure resection patients were selected and randomly divided into control group and study group, 49 cases in each group.And the control group was given routine postoperative treatment, the study group was treated with diosmin tablets on routine postoperative therapy , two groups were treated for seven days for a course of treatment, the wound pain, wound width and wound healing were observed and recorded before and after treatment, blood samples were taken to determine changes in serum inflammatory factors, the clinical efficacy and complications were compared.Results After treatment, the two groups of wound pain, the width of the wound and wound healing rate were decreased, the serum TNF-α, IFN-γ, IL-6 levels were decreased, the difference was statistically significant （P〈0.05）, compared with the control group, the degree of pain, the width of the wound and wound healing rate were lower, the serum TNF-α, IFN-γ, IL-6 content were lower, the average healing time and granulation growth time and remove decay time were shorter, the difference was statistically significant （P〈0.05）.The effective rate of the study group was 91.83%, higher than the control group 75.51%, the difference was statistically significant （P〈0.05）.All patients were followed up, no case falls off phenomenon, there was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Diosmin tablets on the improvement of anal fissure after resection of wound healing has a role in promoting inflammation, reduce the severity of pain conditions.
出处
《中国生化药物杂志》
CAS
2017年第3期243-245,248,共4页
Chinese Journal of Biochemical Pharmaceutics
关键词
地奥司明片
改良肛裂切除术
术后疼痛
创面愈合
diosmin tablets
improvement of anal fissure resection
postoperative pain
wound healing
