摘要
目的探讨IMP3、Ki-67在胃肠胰神经分泌肿瘤(GEP-NEN)中的表达及与临床病理特征的关系。方法收集我院及周边地区自2010年1月~2016年10月确诊的59例GEP-NEN,运用免疫组织化学方法检测患者标本中的IMP3、Ki-67表达情况,结合临床病理特征,应用统计学的方法对结果进行分析。结果 IMP3在GEP-NEN中阳性率为81.36%(48/59),在不同肿瘤直径、有无淋巴结转移、不同肿瘤分期与分级中的表达差异有统计学意义(P<0.05),在是否有远处转移中的表达差异没无统计学意义(P>0.05);Ki-67在GEP-NEN中阳性率为44.68%(26/59),在肿瘤大小、有无淋巴结转移、有无远处转移、病理分级及临床分期中的表达差异均有统计学意义(P<0.01);IMP3、Ki-67表达随着肿瘤体积越大、淋巴结转移、病理分级越高、临床分期越晚阳性率越高。结论 IMP3与Ki-67在GEPNEN的表达可作为判断患者预后的参考因素之一;IMP3可能在GEP-NEN的发生、发展过程中起重要作用。
Objective To investigate the expression of IMP3 and Ki-67 in gastrointestinalopancreatic neuroendocrine neoplasm （GEP-NEN） and its relationship with clinicopathological features.Methods 59 patients with GEP-NEN diagnosed from January 2010 to October 2016 in our hospital and other surrounding areas were collected. Immunohistochemistry was used to detect the expression of IMP3 and Ki-67 in patients＇ specimens.Clinical and pathological features were combined,and the results were statistically analyzed.Results The positive rate of IMP3 in GEP-NEN was 81.36% （48/ 59）.The differences of the expression in different tumor size,whether there was lymph node metastasis or not,different tumor stages and classifications were statistically significant （P〈0.05）.There was no statistical significance in the expression of tumor in terms of whether there was distant metastasis or not （P〉0.05）.The positive rate of Ki-67 in GEP- NEN was 44.68% （26/59）.The differences of the expression in different tumor size,whether there was lymph node metastasis or not,whether there was distant metastasis or not,different pathological grades and clinical stages were sta- tistically significant （P〈0.01）;the positive rate of the expression of IMP3 and Ki-67 was increased with larger tumor size,lymph node metastasis,higher pathological grades,and more advanced clinical stages.Conclusion The expression of IMP3 and Ki-67 in GEP-NEN may be one of the reference factors for determining patients＇ prognosis.IMP3 may play an important role in the development and progression of GEP-NEN.
作者
李有恒
徐洪
曾训
LI You-heng XU Hong ZENG Xun(Department of Pathology,Shekou People＇s Hospital of Shenzhen City in Guangdong Province,Shenzhen 518067,China)
出处
《中国当代医药》
2017年第6期15-18,共4页
China Modern Medicine
基金
广东省深圳市南山区科技局立项课题(2014067)
