摘要
目的我国乳腺癌流行病学演变趋势尚未明确,本研究旨在分析乳腺癌发病年龄、临床分期和分子分型为主的流行病学变化趋势。方法从军事医学科学院附属医院电子病例档案库中,收集2000-01-01-2015-12-31初治原发性乳腺癌患者资料,建立乳腺癌信息数据库,回顾性分析乳腺癌患者发病年龄、临床分期和分子分型的总体分布及其随年代的变化趋势。结果 2 482例初治原发性乳腺癌中位确诊年龄48（19～87）岁,发病高峰年龄段41～60岁,随时间无明显变化。临床分期中,0期（原位癌）和Ⅰ期乳腺癌占比随时间呈显著上升趋势,Ⅲ期乳腺癌比率呈下降趋势,Ⅱ、Ⅳ期乳腺癌比率趋势变化平稳,χ^2=48.60,P〈0.000 1。分子分型中,Luminal型及人表皮生长因子受体2（human epidermal growth factor receptor 2,HER2）阳性乳腺癌均有增加趋势,而三阴型乳腺癌有下降趋势,χ^2=24.81,P〈0.000 1。结论北京地区乳腺癌高峰发病年龄段为41～60岁,中位年龄随时间无明显上升;早期可手术乳腺癌（0～Ⅱ期,T3N1M0期）尤其是原位癌（0期）比例有显著增加的趋势;分子分型中Luminal型及HER2阳性乳腺癌有增加趋势。
OBJECTIVE Breast cancer epidemiology trend has not been clear in China,the purpose of our study was to analyze the epidemiological trend of breast cancer with age,clinical stages and molecular subtypes.METHODS The breast cancer information database was established with clinical datas about patients with primary breast cancer in the Affiliated 307 Hospital of Military Medical Science from 2001.01.01-2015.12.31 and we respectively analyzed the epidemiological features with age,clinical stages and molecular subtypes of these patients.RESULTS The median age in diagnosis of the total 2 482 cases with primary breast cancer was 48（ranged from 19 to 87years old）,with the peak in 41-60 years and had no obvious change with age.The ratio of carcinoma in situ（stage 0）,stageⅠ breast cancer ascended obviously,as the stageⅢ breast cancer decreased,and the trend of stageⅡ and Ⅳ breast cancer was stable（χ^2=48.60,P0.000 1）.Luminal-type and HER2-receptor-positive breast cancer had an increasing trend,while the triple-negative type had a decreasing trend（χ^2=24.81,P0.000 1）.CONCLUSIONS The peak age of breast cancer is 41-60 years old in Beijing,and the trend of early stage breast cancer for surgery（stage 0-Ⅱ,T3N1M0）is increasing,especially the radio of carcinoma in situ（stage 0）.Luminal type and HER2-positive breast cancer is increasing,while the ratio of triplenegative type is decreasing.
作者
韩小伟
柳伟伟
阳泽龙
李建鹏
进淑娟
李念
左思
孟迪
黄焰
HAN Xiao-wei LIU Wei-wei YANG Ze-long LI Nian ZUO Si MENG Di HUANG Yah(Department of Breast Surgery, Affiliated 307 Beijing 100071 ,P. R. China , LI Jian-peng1 , JIN Shu-juan1 , Hospital, Academy of Military Medical Sciences Department of Statistics, Academy of Military Medical Sciences, Beijing 100071 , P. R. China)
出处
《中华肿瘤防治杂志》
CAS
北大核心
2016年第24期1597-1600,共4页
Chinese Journal of Cancer Prevention and Treatment
关键词
乳腺肿瘤
发病年龄
临床分期
分子分型
变化趋势
breast neoplasms
age at onset
clinical stage
molecular typing
epidemiological trend
