摘要
目的:比较经过三种不同方案治疗的中晚期胃癌患者的免疫功能和临床疗效的变化,探索较好的治疗方案。方法:选取102例中晚期胃癌患者,根据不同维持治疗的方案分为三组:DC-CIK维持治疗组(DC-CIK组)33例、单药化疗维持治疗组(替吉奥组)33例(替吉奥单药治疗)、对照组36例(无维持治疗);经过3个周期的治疗,观察比较三组的临床疗效(mPFS)及免疫功能(CD4+/CD8+)的变化。结果:三组的中位PFS分别为12.0个月、11.0个月和7.0个月,组间差异有统计学意义(P<0.05)。免疫功能的变化在DC-CIK组中CD4+/CD8+的比例显著增高(P<0.05),替吉奥组中CD4+/CD8+的比例下降(P<0.05),而在对照组中CD4+/CD8+在治疗前、后的差异无统计学意义(P>0.05)。结论:DC-CIK维持治疗可以提高患者的免疫功能,单一的化疗药物治疗会降低患者的免疫功能,而免疫功能的高低可以影响患者的临床疗效,因此对中晚期胃癌患者进行DC-CIK维持治疗在临床上是有研究意义的。
Objective：To compare Clinical efficacy and immune modulation in patients with advanced gastric carcinoma in three maintenance treatments and to explore the better solution.Methods：102gastric carcinoma patients（stageⅢ~Ⅳ）were retrospectively analyzed,they were divided into three groups,according to the different maintenance treatment scheme：DC-CIK maintenance group of 33 cases,Chemotherapy maintenance group of 33cases（S-1mono-therapy）,observation group of 36cases（without maintenance treatment）.Three cycles of treatment were administered to three groups,short-term efficacy and immunologic functions were compared between groups.Results：The median PFS of the three groups were 12.0months,11.0months and 7.0months.There was significant difference between three groups（P〈0.05）.Detection of immune function：after treatment the ratio of CD4＋/CD8＋was significantly increased in DC-CIK maintenance group（P〈0.05）,the ratio of CD4＋/CD8＋was reduced in chemotherapy group（P〈0.05）,but there was no significant difference in the ratio of CD4＋/CD8＋before and after treatment in the observation group（P〉0.05）.Conclusion：DC-CIK maintenance treatment can improve the immune function of the patients,single agent chemotherapy will reduce immune function of the patients,and immune function may affect the patient PFS.Therefore,the advanced gastric cancer of DC-CIK maintenance therapy is worthy of clinical randomized controlled study.
出处
《医学理论与实践》
2017年第5期627-629,共3页
The Journal of Medical Theory and Practice
关键词
DC-CIK维持治疗
中晚期胃癌
化疗维持治疗
临床疗效
DC-CIK maintenance treatment
Advanced gastric carcinoma
Chemotherapy maintenance treatment
Clin ical efficacy
