摘要
目的:观察复方桔梗合剂的止咳和抗炎效果。方法:建立豚鼠磷酸组胺致咳、小鼠浓氨水致咳模型,观察复方桔梗合剂的止咳效果;采用二甲苯致小鼠耳廓肿胀,脂多糖(LPS)对小鼠RAW264.7巨噬细胞进行诱导,观察复方桔梗合剂的抗炎效果。结果:复方桔梗合剂干预后,动物的咳嗽潜伏期明显延长,咳嗽次数减少;二甲苯导致的小鼠耳廓肿胀程度减轻,脂多糖(LPS)诱导的RAW264.7巨噬细胞内NO的含量显著降低,i NOS的活性受抑制。结论:复方桔梗合剂具有止咳和抗炎作用。
Objective： To observe the effects of the compounds of Jiegeng （Platycodon grandiflornu） on cough and inflammatory. Methods： The anti-asthma of the compounds of Platycodon grandiflornu was evaluated with the guinea pigs model induced by histamine phosphate and the mice model induced by ammonia water, and the anti-inflammatory effect was observed by building mice dimethylbenzene auricle swelling model and the RAW246.7 macrophages caused by LPS. Results： After the animals were treated with the compounds of Platycodon grandiflornu, the cough incubation period of animals was significantly prolonged, and the cough times decreased, the auricle swelling of mice by dimethylbenzene-induced were obviously reduced： the NO content in RAW264.7 macrophages induced by LPS decreased, and the activity of iNOS was inhibited. Conclusion： The compounds of Platycodon grandiflornu possess the effects of the cough relieving and anti-inflammatory.
作者
刘海锋
黄山
玄光善
周海燕
李斌
崔永日
LIU Hai-feng HUANG Shan XUAN Guang-shan ZHOU Hai-yan LI Bin CUI Yong-ri(College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao Shandong 266042, China Qingdao Xinshengran Health Industry Co. Ltd., Qingdao Shandong 266105, China)
出处
《中医药导报》
2017年第4期59-62,共4页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
关键词
复方桔梗合剂
止咳
抗炎
巨噬细胞
小鼠
豚鼠
the compounds of Platycodon Grandiflornu
anti-asthma
anti-inflammatory
RAW264.7 macrophages
mice
guinea pig
