摘要
目的运用Meta分析的方法综合评估血管内皮生长因子(VEGF)对恶性胸腔积液的诊断价值。方法通过计算机检索Best Evidence、Cochrane library、Pub Med、Web of Science、中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)、维普数据库(VIP)、万方数据库等,并结合网上查询(www.google.cn;www.baidu.com)及文献追溯等方法,收集2000年1月至2016年5月国内外发表的相关文献进行筛选、质量评价及资料提取后,采用Meta-Disc 1.4和Rev Man 5.3软件进行资料分析,并通过汇总各研究的灵敏度、特异度、阳性似然比、阴性似然比、诊断比值比以及绘制总的受试者工作曲线(SROC)评估VEGF对恶性胸腔积液的诊断价值。结果共搜索文献747篇,最终纳入10篇,样本量为893例患者,包括468例恶性胸腔积液及425例良性胸腔积液。VEGF诊断恶性胸腔积液的汇总灵敏度为0.72(95%CI 0.67,0.76),汇总特异度为0.80(95%CI 0.75,0.83),汇总阳性似然比为3.81(95%CI2.40,6.06),汇总阴性似然比为0.37(95%CI 0.28,0.48),汇总诊断比值比为12.79(95%CI 6.33,25.84),SROC曲线下面积(AUC)为0.8384。结论 VEGF诊断恶性胸腔积液具有较高的灵敏度和特异度,可作为恶性胸腔积液非侵入性诊断的辅助工具。
Objective To asses the diagnostic value of vascular endothelial growth factor（ VEGF） in malignant pleural effusion by Meta-analysis. Methods We not only searched Best Evidence,Cochrane library,Pub Med,CBM,CNKI,VIP,Wanfang Data et al but also checked online（ www. google. cn; www. baidu. com）and traced literature to gather the relevant research literature on VEGF for the diagnosis of malignant pleural effusion from January 2000 to May 2016. Then we used Meta- Disc 1. 4 and Rev Man 5. 3 software for data analysis to evaluate the diagnostic value of VEGF in malignant pleural effusion by calculating the pooled sensitivity,specificity,the likelihood ratio（ LR）,diagnostic odds ratios（ DOR） and conducting summary receiver operating characteristic curve（ SROC curve）. Results Totally 747 articles were searched and finally10 were included with sample size of 893 cases,including 468 cases of malignant pleural effusion and 425 cases of benign pleural effusion. The summary estimates for VEGF in the diagnosis of MPE were： sensitivity 0. 72（ 95% CI 0.67,0.76）,specificity0.80（ 95% CI 0.75,0.83）,positive likelihood ratio 3.81（ 95% CI 2.40,6.06）,negative likelihood ratio 0.37（ 95% CI 0.28,0.48）,diagnostic odds ratio 12.79（ 95% CI 6.33,25.84）and the SROC area under the curve（ AUC） 0. 8384. Conclusions VEGF in pleural effusion has potential diagnostic value with advanced sensitivity and specificity and it can be used as adjunct tool for non-invasive diagnosis of malignant pleural effusion.
出处
《中华肺部疾病杂志（电子版）》
CAS
2017年第1期29-34,共6页
Chinese Journal of Lung Diseases(Electronic Edition)
基金
国家临床重点专科建设项目(2012.649)
关键词
血管内皮生长因子
胸腔积液
诊断
META分析
Vascular endothelial growth factor
Pleural effusion
Diagnosis
Meta-analysis
