摘要
目的观察丙泊酚注射剂治疗活动过多型谵妄的临床疗效及安全性。方法将100例活动过多型谵妄患者分为对照组48例和试验组52例。对照组先予以负荷剂量1μg·kg^(-1)右美托咪定在10 min内静脉推注,后以0.52~0.70μg·kg^(-1)·h^(-1)持续静脉泵入10 min;试验组先予以0.5 mg·kg^(-1)丙泊酚,静脉推注,后以0.5~1.0 mg·kg^(-1)·h^(-1)持续静脉泵入5 min。2组患者均治疗2 h。观察2组患者的临床疗效和药物不良反应的发生情况。结果治疗后,试验组和对照组的重症谵妄筛查表评分分别为(1.26±0.57),(2.53±0.76)分;总谵妄持续时间分别为(20.15±4.67),(26.46±5.12)h;躁动型谵妄持续时间分别为(8.32±2.48),(12.32±4.14)h;谵妄复发率分别为3.85%,18.75%;机械通气时间分别为(50.65±8.84),(60.67±7.98)h;拔管时间分别为(52.76±7.98),(62.38±8.95)h;住重症监护病房时间分别为(114.59±10.76),(123.43±9.87)h,差异均有统计学意义(P<0.05)。2组患者的药物不良反应以低血压、心动过缓、急性肌张力障碍为主。试验组和对照组的药物不良反应发生率分别为21.15%和27.08%,差异无统计学意义(P>0.05)。结论丙泊酚治疗活动过多型谵妄患者的临床疗效确切,且不增加药物不良反应的发生率。
Objective To observe the clinical efficacy and safety of propofol injection in the treatment of hyperactive delirium. Methods One hundred patients with hyperactive delirium were randomly divided into control group（ n = 48 cases） and treatment group（ n = 52 cases）.Control group was given loading dose of 1 μg·kg-1dexmedetomidine for10 min with intravenous push,then continuous intravenous infusion for10 min with 0. 52-0. 70 μg · kg-1·h-1. Treatment group was given0. 5 mg · kg-1propofol with intravenous push,then continuous intravenous infusion for 5 min with 0. 5-1. 0 μg · kg-1·h-1. Two groups were treated for 2 h. The clinical efficacy and adverse drug reactions were compared between two groups. Results After treatment,the main indexes in treatment and control groups were compared between two groups： the intensive care delirium screening checklist were（ 1. 26 ± 0. 57）,（ 2. 53 ± 0. 76） points; total delirium duration were（ 20. 15 ± 4. 67）,（ 26. 46 ± 5. 12） h; duration of restless delirium were（ 8. 32 ± 2. 48）,（ 12. 32 ± 4. 14） h; delirium recurrence rates were3. 85%, 18. 75%; duration of mechanical ventilation were（ 50. 65 ± 8. 84）,（ 60. 67 ± 7. 98） h; extubation time were（ 52. 76 ± 7. 98）,（ 62. 38 ± 8. 95） h; intensive care unit time were（ 114. 59 ± 10. 76）,（ 123. 43 ± 9. 87） h,with significant difference（ P〈0. 05）. The adverse drug reactions in two groups were based on hypotension,bradycardia and acute dystonia. The incidences of adverse drug reactions in treatment and control groups were 21. 15% and 27. 08% without significant difference（ P〈0. 05）. Conclusion Propofol injection has a definitive clinical efficacy in the treatment of hyperactive delirium,without increasing the incidence of adverse drug reactions.
作者
吴颖
刘淑红
刘亚晶
亢宏山
彭丽
WU Ying LIU Shu - hong LIU Ya- jing KANG Hong -shan PENG Li(Intensive Care Unit, Harrison International Peace Hospital, Hengshui 053000, Hebei Province, Chin)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2017年第5期408-410,共3页
The Chinese Journal of Clinical Pharmacology
基金
衡水市科学研究与发展计划(医药卫生)基金资助项目(14019A)
