摘要
目的:观察清湿热方对湿热痹阻型急性期痛风性关节炎的临床疗效。方法:将203例湿热痹阻型痛风性关节炎患者随机分为2组。对照组口服依托考昔片治疗,治疗组给予口服依托考昔片联合清湿热方治疗,检测比较2组血尿酸(BUA)、血沉(ESR)、C-反应蛋白(CRP),观察2组疗效。结果:总有效率治疗组为95.00%,对照组为84.85%,2组比较,差异有统计学意义(χ~2=5.671 1,P=0.017 2<0.05)。2组治疗前后的VAS评分经秩和检验,差异有统计学意义(P<0.05);2组治疗前后ESR、CRP均降低(P<0.05);治疗组BUA降低(P<0.05),对照组BUA无明显变化(P<0.05)。2组治疗后ESR、CRP、BUA比较,差异无统计学意义(P>0.05)。治疗组无不良反应发生,对照组心悸不安2例,2组比较,差异无统计学意义(χ~2=2.040 7,P=0.153 1>0.05)。结论:依托考昔片联合清湿热方治疗湿热痹阻型痛风性关节炎具有较好的疗效。
Objective：To observe the clinical effect of Qingshire prescription for moist heat arthralgia spasm type acute gouty arthritis.Methods：Divided 203 patients with damp-heat stagnation type acute gouty arthritis into two groups.The control group was given oral etoricoxib tablets,and the treatment group was given oral etoricoxib tablets combined with Qingshire prescription.Detected and compared blood uric acid（BUA）,erythrocyte sedimentation rate（ESR）,C- reactive protein（CRP） of the two groups,and observed curative effect of the two groups.Results：The total effective rate was95.00%in the treatment group,and was 84.85%in the control group,the difference being significant（χ^2=5.671 1,P=0.01720.05）.Compared visual analogue scale（VAS） of the two groups by rank and test before and after treatment,the difference was significant（P〈0.05）.After treatment,ERS,CRP of the two groups were both decreased（P〈0.05）;BUA of the treatment group was decreased（P〈0.05）,and there was no significant change in BUA of the control group（P〈0.05）.Compared ESR,CRP and BUA of the two groups after treatment,there was no significant difference（P〉0.05）.There was no adverse reaction in the treatment group,and there were two cases of heart palpitations in the control group,the difference showed no significance（χ^2= 2.040 7,P=0.153 10.05）.Conclusion：Etoricoxib tablets combined with Qingshire prescription has a good curative effect in treating damp- heat stagnation type gouty arthritis.
作者
廖志浩
叶国强
陈希
王浩
LIAO Zhihao YE Guoqiang CHEN Xi WANG Hao
出处
《新中医》
CAS
2017年第3期66-68,共3页
New Chinese Medicine
基金
广州中医药大学创新强校项目(A1-AFD015151Z1562)
关键词
急性痛风性关节炎
湿热痹阻型
清湿热方
依托考昔片
Acute gouty arthritis
Moist heat arthralgia spasm type
Qingshire prescription
Etoricoxib tablets
