摘要
目的探讨盆腔超声对女童中枢性性早熟(CPP)的临床诊断价值。方法选取因乳腺发育初次就诊的女童219例,以促性腺激素释放激素激发试验阳性(黄体生成素峰值>5 U/L)为诊断金标准,将患儿分为CPP组128例和单纯性乳腺早发育(PT)组91例,经盆腔超声分别测量并比较两组患儿子宫和卵巢的长径、前后径、横径、体积,以及最大卵泡直径。对超声测量参数与黄体生成素峰值进行相关性分析;绘制超声诊断CPP的受试者工作特征(ROC)曲线,并计算其曲线下面积。结果 CPP组子宫的长径和体积、卵巢的长径和体积,以及最大卵泡直径均显著大于PT组[(2.51±0.43)cm vs.(1.93±0.29)cm,(1.86±1.08)ml vs.(1.06±0.51)ml;(2.58±0.50)cm vs.(2.02±0.51)cm,(1.81±1.09)ml vs.(0.98±0.46)ml;(0.67±0.17)cm vs.(0.21±0.12)cm)],差异均有统计学意义(均P<0.05)。CPP组的子宫长径、子宫体积、卵巢长径、卵巢体积及最大卵泡直径与黄体生成素峰值均呈正相关,其ROC曲线下面积分别为0.70、0.81、0.59、0.63及0.88。结论经盆腔超声测量子宫卵巢各形态学参数对CPP有一定的诊断价值,其中以子宫体积和最大卵泡直径的诊断价值最高。
ABSTRUCT Objective To evaluate the diagnostic value of pelvic ultrasound in girls with central precocious puberty（CPP）. Methods A total of 219 girls with early breast development were enrolled and divided into two groups according to the gonadotropin-releasing hormone stimulation test（Gn RH,A peak LH concentration of at least 5 U/L was classified as CPP）,including CPP group（128 cases）and simple breast developmen（tpremature thelarche,PT 91 cases）group. The uterine length,width,thickness and volume and ovarian length,width,thickness and volume,diameter of the maximal follicle of girs in both groups were measured by pelvic ultrosonography and compared.Correlation analysis was performed between ultrasonic parameters and results of Gn RH test.The optimum cutoff values were confirmed through area under the receiver operating characteristic curve（ROC）. Results Compared with the PT group,the uterine length,uterine volume,ovarian length,ovarian volume and the diameter of maximal follicle were significantly larger in the CPP group[（2.51±0.43）cm vs（.1.93±0.29）cm,（1.86±1.08）ml vs.（1.06±0.51）ml,（2.58±0.50）cm vs（.2.02±0.51）cm,（1.81±1.09）ml vs（.0.98±0.46）ml,（0.67±0.17）cm vs（.0.21±0.12）cm].The differences were statistically significan（tall P〈0.05）.The morphometric parameters above were positively correlated with LH peak value in CPP girls.The areas under ROC curve of uterine length,uterine volume,ovarian length,ovarian volume and diameter of maximal follicle of girls in CPP group were 0.70,0.81,0.59,0.63,0.88, respectively. Conclusion The pelvic ultrasound has a certain value in the diagnosis of CPP in girls,the uterine volume and diameter of maximal follicle were especially.
出处
《临床超声医学杂志》
2017年第2期105-108,共4页
Journal of Clinical Ultrasound in Medicine
关键词
超声检查
经盆腔
中枢性性早熟
子宫
卵巢
Ultrasonography
pelvic
Central precocious puberty
Uterus
Ovary
