摘要
目的:观察"鸡尾酒"疗法对持续及慢性原发免疫性血小板减少症儿童患者的临床疗效。以调节性T细胞(Regulatory T cells,Treg)为切入点,从免疫失耐受角度探索儿童持续及慢性ITP的发病机制。方法:纳入22例2015年6月—2015年12月在北京中医药大学东直门医院儿科门诊就诊的ITP患儿,以中药、小剂量醋酸泼尼松片、多维片、复方芦丁片组成的"鸡尾酒"疗法为干预措施,疗程12周。比较治疗前后患儿血小板计数、Treg细胞水平的变化。结果:治疗总有效率63.6%,其中完全反应54.5%(P<0.05)。治疗前后自身对照,81.8%持续及慢性ITP儿童患者的体内CD4+CD25+Foxp3+Treg细胞呈现不同程度增加(P<0.05)。结论:"鸡尾酒"疗法治疗持续及慢性ITP儿童患者的临床疗效确切;持续及慢性ITP患者机体免疫失耐受,"鸡尾酒"疗法能改善Treg细胞水平,恢复正常的免疫耐受。
Objective：Observe the clinical effect of＂cocktail＂therapy against persist and chronic immune thrombocytopenia（ITP）of children. We take the regulatory T cells（Treg）as the breakthrough point,trying to explore the pathogenesis in children persist and chronic ITP from the perspective of immune tolerance loss. Methods：Study 22 children who have were diagnosed with persist or chronic ITP and treatingfrom June 2015 to December 2015 in Dongzhimen hospital affiliated to Beijing university of Chinese medicine. Treat them with＂cocktail＂therapy which is composed by traditional Chinese medicine（TCM）,small dose of Prednisone Acetate Tablets,Multivitamin Tablets and Compound Rutin Tablets for intervention for 12 weeks. We compare the changes of platelet count and Treg cells level. Results：The total effective rate is 63.6%,among which fully reflect was 54.5%（P〈0.05）. The before and after self control study indicate that 81.8% the CD4^＋ CD25^＋ Foxp3^＋ Treg cells of children with persist and chronic ITP increased（P〈0.05）in different degree. Conclusion：＂Cocktail＂therapy is effective in treating persist and chronic ITP children. Immune tolerance loss exists in persist and chronic ITP patients.＂Cocktail＂therapy can improve the level of Treg cells and restore the immune tolerance.
出处
《辽宁中医药大学学报》
CAS
2017年第3期146-149,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
北京中医药大学自主课题(2015-JYB-XS154)
