摘要
目的探讨慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)血清淀粉样蛋白A(serum amyloid A,SAA)及血浆纤维蛋白原与病情严重程度的相关性。方法选择50例AECOPD患者及20位健康对照者。通过COPD评估测试(CAT)问卷对急性加重期患者生活质量进行分级。应用酶标仪、全自动凝血分析仪测定实验组及对照组的SAA及纤维蛋白原浓度。结果在COPD急性加重期,SAA及纤维蛋白原浓度高于对照组(P<0.05)。AECOPD患者分级后,SAA、纤维蛋白原浓度与CAT分值具有关联性(P<0.05)。结论在AECOPD期,SAA及纤维蛋白原浓度变化与患者的病情严重程度呈正相关。
Objective To study the association of serum amyloid A （SAA） and plasma fibrinogen concentration with the severity of patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods Total 50 patients of AECOPD and 20 healthy controls were selected. Experimental group were scored and classified by CAT （Chronic obstructive pulmonary disease assessment tests）. SAA was measured by enzyme-labeled instrument. Plasma fibrinogen was measured by automatic coagulation analyzer. Results In patients with AECOPD, SAA and plasma fibrinogen levels were more than those in healthy controls （P 〈 0.05 ）. While, in the different classifed patients with AECOPD, the changes of SAA and plasma fibrinogen were associated with score of CAT （P 〈 0. 05）. Conclusion SAA and plasma fibrinogen levels are positive correlation with increasing severity of patients with AECOPD.
出处
《哈尔滨医科大学学报》
CAS
2016年第6期555-557,561,共4页
Journal of Harbin Medical University
