摘要
目的分析探讨丙氨酰谷氨酰胺(Gln)对重型颅脑损伤(SCI)小儿患者肠粘膜通透性及血浆二胺氧化酶的影响。方法本院82例小儿SCI患者随机分为研究组及对照组,研究组在对照组治疗基础上给予Gln治疗,测定其乳果糖排泄率、血浆内毒素及血浆二胺氧化酶水平并进行统计学分析。结果研究组乳果糖排泄率,内毒素及血浆二胺氧化酶水平显著性低于对照组,且随时间推移逐渐降低。结论重型颅脑损伤患儿给予Gln,可有效的降低肠粘膜通透性及上皮细胞坏死,对肠粘膜屏障作用的重塑具有重要意义,对于减少炎症的发生有着良好的作用。
Objective To analyze and explore the effect of alanyl-glutamine （Gln）on intestinal mueosal permeability and plasma diamine oxidase in children with severe eranioeerebral injury （SCI）. Methods 82 cases of children with SCI in our hospital, were randomly divided into study group and control group, the study group Gln was applied based on the treatment in the control group.The laetulose excretion rate, plasma endotoxin and plasma diamine oxidase were detected and statistical analysis. Results The laetulose excretion rate and plasma endotoxin and plasma diamine oxidase level in the study group decreased significantly compared to the control group,and then gradually decreased time-dependent. Conclusion Postoperative administration of Gln in children with SCI showed great effect of reducing the permeability of intestinal mueosa and epithelial cell necrosis, had an important role in the remod- eling of intestinal mueosal barrier and had a good prognosis for reducing the occurrence of inflammation.
出处
《浙江创伤外科》
2017年第1期11-13,共3页
Zhejiang Journal of Traumatic Surgery
