摘要
目的通过mtea分析方法评价使用宫铜300宫内节育器(intrauterine device,IUD)因症终止发生情况及其相关影响因素,为安全使用IUD提供科学依据。方法利用计算机检索Pub Med、Embase、POPLINE、CNKI、CBMDisc等数据库检索与宫铜300因症终止相关文献,剔除不符合要求的文献,采用Open Meta-analyst软件对数据进行分析与合并。结果共检索到6 062篇文献,根据纳入及排除标准,最终纳入涉及宫铜300 IUD因症终止的文献19篇,均为随机对照试验(randomized controlled trial,RCT)RCT或准RCT,共计20 414例观察对象,其中宫铜300 IUD组6 017例。mta分析表明:因症终止的发生率随使用时间延长呈现上升趋势。城市人群在12个月时因症终止的发生率高于农村对象,且差异有统计学意义(P<0.05)。放置宫铜300 IUD后12个月时,月经间期放置组的因症终止发生率(4.3%)高于人流术后即时放置组(4.0%),但差异无统计学意义(P>0.05)。结论首次报道宫铜300 IUD因症终止发生情况及影响因素的meta分析结果,建议医务人员应注意宫铜300 IUD使用后的定期医学随访,对IUD使用对象应加强宣教和随访,以减少因症终止的发生。
Objective Meta - analysis method was used to evaluate the medical removal rate of intrauterine device （IUD） GCu300 and related influencing factors, providing scientific evidence for safe use of IUD. Methods English databases including PubMed,EMBASE and CENTRAL, websites including Current Controlled MetaRegister, FDA, WHO and related enterprises, and Chinese databases including CBMdisc, CMCI, CNKI, VIP and Wanfang were searched. Software of Open Meta - analyst was used to analyze and incorporate data. Results 6 062 Chinese and English literatures were searched preliminarily, but only 13 RCTs and quasi RCTs of GCu300 were recruited for further analysis according to the inclusion and exclusion criteria. There were a total of 20 414 women, including 6 017 IUD users（ GCu300 group）. Medical removal rate of GCu300 showed an upward trend with the increasing time of GCu300 IUD usage. At the 12 month follow - up, medical removal rate of GCu300 of urban population was significantly higher than that of the rural ones （P 〈 0. 05）. Medical removal rate of GCu300 inserted during menstrual period （4.3%） was significantly higher than immediately after artificial abortion at the 12 month follow - up. Conclusion Medical removal rate and related influencing factors of GCu300 IUD based on meta - analysis were first reported. It is recommended that medical professionals should pay attention to regular follow - ups, strengthen education after the use of GCu300 IUD to reduce the occurrence of medical removals.
出处
《中国计划生育和妇产科》
2017年第3期6-9,26,共5页
Chinese Journal of Family Planning & Gynecotokology
基金
美国中华医学基金会(CMB)开放基金课题资助(CMB Grant:13-153)
江苏省计划生育科研所启动基金项目(项目编号:JSFP2014003)
